(E)-4-Hydroxy-3-methylbut-2-enyl Diphosphate: An Intermediate in the Formation of Terpenoids in Plant Chromoplasts

The missing link in the new deoxyxylulose phosphate metabolic pathway leading to the biosynthesis of plant terpenoids has been identified. The intermediate between the cyclic diphosphate 1 and the basic isoprenoid building blocks dimethylallyl diphosphate and isopentenyl diphosphate has been shown f...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2002-07, Vol.41 (14), p.2604-2607
Main Authors: Gao, Wenyun, Loeser, Reik, Raschke, Maja, Dessoy, Marco A., Fulhorst, Michael, Alpermann, Henriette, Wessjohann, Ludger A., Zenk, Meinhart H.
Format: Article
Language:English
Subjects:
biosynthesis
Chromatography, High Pressure Liquid
diphosphates
Diphosphates - chemistry
isoprenes
isotopic labeling
Plants - metabolism
Plastids - metabolism
Terpenes - metabolism
terpenoids
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Summary:The missing link in the new deoxyxylulose phosphate metabolic pathway leading to the biosynthesis of plant terpenoids has been identified. The intermediate between the cyclic diphosphate 1 and the basic isoprenoid building blocks dimethylallyl diphosphate and isopentenyl diphosphate has been shown for the first time to be (E)‐4‐hydroxy‐3‐methylbut‐2‐enyl diphosphate (2) by incorporation of tritium‐labeled 2 into phytoene.
ISSN:1433-7851
1521-3773
DOI:10.1002/1521-3773(20020715)41:14<2604::AID-ANIE2604>3.0.CO;2-S