Neurovascular disease, antioxidants and glycation in diabetes

People with diabetes are ten to fifteen times more likely to have a lower limb amputation (LLA) than non‐diabetic individuals. Fifteen percent of people with diabetes will develop a foot ulcer during their lifetime, the rate of major amputation amongst diabetic individuals continues to rise, foot pr...

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Bibliographic Details
Published in:Diabetes/Metabolism Research and Reviews 2002-07, Vol.18 (4), p.260-272
Main Authors: Dickinson, P. J., Carrington, A. L., Frost, G. S., Boulton, A. J. M.
Format: Article
Language:English
Subjects:
Amputation
antioxidants
Antioxidants - therapeutic use
Associated diseases and complications
Biological and medical sciences
diabetes
Diabetes Complications
Diabetes. Impaired glucose tolerance
Diabetic Angiopathies - prevention & control
Diabetic Foot - etiology
Diabetic Foot - prevention & control
Diabetic Foot - surgery
Diabetic Neuropathies - prevention & control
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
glycation
Glycation End Products, Advanced - metabolism
Humans
Medical sciences
neuropathy
peripheral vascular disease
vitamins
Vitamins - therapeutic use
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Summary:People with diabetes are ten to fifteen times more likely to have a lower limb amputation (LLA) than non‐diabetic individuals. Fifteen percent of people with diabetes will develop a foot ulcer during their lifetime, the rate of major amputation amongst diabetic individuals continues to rise, foot problems remain the commonest reason for diabetes‐related hospitalisation and recurrence rates in patients with previous foot ulcers are 50% or more. Hyperglycaemia‐induced oxidative stress has been shown to result in decreased nerve conduction velocity, and decreased endoneural blood flow—both precursors for neuropathy. Vitamin antioxidants have been shown to be effective therapy in experimental models in reducing free radical species and inhibiting the oxidative process in diabetes subjects. Little work has been published, however, regarding the dietary use of antioxidants from foods, and their specific effects on neurovascular disease and glycation within the diabetes population. Aetiological and prevention studies with dietary antioxidants from foods aimed at the complex nature of foot problems in diabetes are needed. Copyright © 2002 John Wiley & Sons, Ltd.
ISSN:1520-7552
1520-7560
DOI:10.1002/dmrr.305