Markers for depression in Parkinson's disease

Leentjens AFG, Lousberg R, Verhey FRJ. Markers for depression in Parkinson's disease. Acta Psychiatr Scand 2002: 106: 196–201. © Blackwell Munksgaard 2002. Objective: To assess whether general risk factors for depression are also markers of depression in patients with Parkinson's disease (...

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Published in:Acta psychiatrica Scandinavica 2002-09, Vol.106 (3), p.196-201
Main Authors: Leentjens, A. F. G., Lousberg, R., Verhey, F. R. J.
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Aged
Biological and medical sciences
Biomarkers
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Depression
depressive disorder
Depressive Disorder - complications
Depressive Disorder - diagnosis
Depressive Disorder - psychology
Female
Humans
Male
Medical sciences
Mood disorders
Neurology
Parkinson Disease - complications
Parkinson Disease - psychology
Parkinson's disease
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
risk factor
Risk Factors
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Summary:Leentjens AFG, Lousberg R, Verhey FRJ. Markers for depression in Parkinson's disease. Acta Psychiatr Scand 2002: 106: 196–201. © Blackwell Munksgaard 2002. Objective: To assess whether general risk factors for depression are also markers of depression in patients with Parkinson's disease (PD) and to identify additional disease‐specific markers. Method: A two‐step logistic regression was performed on data from 161 consecutively referred PD patients, 40 of whom suffered from major depressive disorder. A first logistic model was created with five general risk factors for depression. Next, five potential disease‐specific markers were added to see whether this would improve the model. Results: The logistic model of general risk factors for depression also predicted depression in PD patients. A family history of depression was the most important marker. `Right‐sided onset' was the only disease‐specific marker that improved the model. Conclusion: Established risk factors for depression in the general population are also markers of depression in PD. The importance of correcting for general risk factors for depression in the search for disease‐specific risk factors is stressed.
ISSN:0001-690X
1600-0447
DOI:10.1034/j.1600-0447.2002.02045.x