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Markers for depression in Parkinson's disease
Leentjens AFG, Lousberg R, Verhey FRJ. Markers for depression in Parkinson's disease. Acta Psychiatr Scand 2002: 106: 196–201. © Blackwell Munksgaard 2002. Objective: To assess whether general risk factors for depression are also markers of depression in patients with Parkinson's disease (...
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| Published in: | Acta psychiatrica Scandinavica 2002-09, Vol.106 (3), p.196-201 |
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| container_issue | 3 |
| container_start_page | 196 |
| container_title | Acta psychiatrica Scandinavica |
| container_volume | 106 |
| creator | Leentjens, A. F. G. Lousberg, R. Verhey, F. R. J. |
| description | Leentjens AFG, Lousberg R, Verhey FRJ. Markers for depression in Parkinson's disease. Acta Psychiatr Scand 2002: 106: 196–201. © Blackwell Munksgaard 2002.
Objective: To assess whether general risk factors for depression are also markers of depression in patients with Parkinson's disease (PD) and to identify additional disease‐specific markers.
Method: A two‐step logistic regression was performed on data from 161 consecutively referred PD patients, 40 of whom suffered from major depressive disorder. A first logistic model was created with five general risk factors for depression. Next, five potential disease‐specific markers were added to see whether this would improve the model.
Results: The logistic model of general risk factors for depression also predicted depression in PD patients. A family history of depression was the most important marker. `Right‐sided onset' was the only disease‐specific marker that improved the model.
Conclusion: Established risk factors for depression in the general population are also markers of depression in PD. The importance of correcting for general risk factors for depression in the search for disease‐specific risk factors is stressed. |
| doi_str_mv | 10.1034/j.1600-0447.2002.02045.x |
| format | article |
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Objective: To assess whether general risk factors for depression are also markers of depression in patients with Parkinson's disease (PD) and to identify additional disease‐specific markers.
Method: A two‐step logistic regression was performed on data from 161 consecutively referred PD patients, 40 of whom suffered from major depressive disorder. A first logistic model was created with five general risk factors for depression. Next, five potential disease‐specific markers were added to see whether this would improve the model.
Results: The logistic model of general risk factors for depression also predicted depression in PD patients. A family history of depression was the most important marker. `Right‐sided onset' was the only disease‐specific marker that improved the model.
Conclusion: Established risk factors for depression in the general population are also markers of depression in PD. The importance of correcting for general risk factors for depression in the search for disease‐specific risk factors is stressed.</description><identifier>ISSN: 0001-690X</identifier><identifier>EISSN: 1600-0447</identifier><identifier>DOI: 10.1034/j.1600-0447.2002.02045.x</identifier><identifier>PMID: 12197857</identifier><identifier>CODEN: APYSA9</identifier><language>eng</language><publisher>Oxford UK: Munksgaard International Publishers</publisher><subject>Adult and adolescent clinical studies ; Aged ; Biological and medical sciences ; Biomarkers ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Depression ; depressive disorder ; Depressive Disorder - complications ; Depressive Disorder - diagnosis ; Depressive Disorder - psychology ; Female ; Humans ; Male ; Medical sciences ; Mood disorders ; Neurology ; Parkinson Disease - complications ; Parkinson Disease - psychology ; Parkinson's disease ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; risk factor ; Risk Factors</subject><ispartof>Acta psychiatrica Scandinavica, 2002-09, Vol.106 (3), p.196-201</ispartof><rights>2002 INIST-CNRS</rights><rights>Copyright Blackwell Munksgaard 2002.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4355-6c691f8b86f1f64b3145a54ebe6dd4618957cba7d814961be95b5619f28855063</citedby><cites>FETCH-LOGICAL-c4355-6c691f8b86f1f64b3145a54ebe6dd4618957cba7d814961be95b5619f28855063</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13903924$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12197857$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Leentjens, A. F. G.</creatorcontrib><creatorcontrib>Lousberg, R.</creatorcontrib><creatorcontrib>Verhey, F. R. J.</creatorcontrib><title>Markers for depression in Parkinson's disease</title><title>Acta psychiatrica Scandinavica</title><addtitle>Acta Psychiatr Scand</addtitle><description>Leentjens AFG, Lousberg R, Verhey FRJ. Markers for depression in Parkinson's disease. Acta Psychiatr Scand 2002: 106: 196–201. © Blackwell Munksgaard 2002.
Objective: To assess whether general risk factors for depression are also markers of depression in patients with Parkinson's disease (PD) and to identify additional disease‐specific markers.
Method: A two‐step logistic regression was performed on data from 161 consecutively referred PD patients, 40 of whom suffered from major depressive disorder. A first logistic model was created with five general risk factors for depression. Next, five potential disease‐specific markers were added to see whether this would improve the model.
Results: The logistic model of general risk factors for depression also predicted depression in PD patients. A family history of depression was the most important marker. `Right‐sided onset' was the only disease‐specific marker that improved the model.
Conclusion: Established risk factors for depression in the general population are also markers of depression in PD. The importance of correcting for general risk factors for depression in the search for disease‐specific risk factors is stressed.</description><subject>Adult and adolescent clinical studies</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Depression</subject><subject>depressive disorder</subject><subject>Depressive Disorder - complications</subject><subject>Depressive Disorder - diagnosis</subject><subject>Depressive Disorder - psychology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mood disorders</subject><subject>Neurology</subject><subject>Parkinson Disease - complications</subject><subject>Parkinson Disease - psychology</subject><subject>Parkinson's disease</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>risk factor</subject><subject>Risk Factors</subject><issn>0001-690X</issn><issn>1600-0447</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><recordid>eNqNkE1P4zAQhi0EWgq7fwHlAntKGCf-PCHa5Uti-dgFwc1yEkdySZPioaL8exxawZXTeDTPvB49hCQUMgoFO5xmVACkwJjMcoA8gxwYz5YbZPQ52CQjAKCp0PC4TXYQp7HlFNQPsk1zqqXickTSvzY8uYBJ04ekdvPgEH3fJb5LbuLEd9h3vzGpPTqL7ifZamyL7te67pL705O7yXl6eX12MTm-TCtWcJ6KSmjaqFKJhjaClQVl3HLmSifqmgmqNJdVaWWtKNOClk7zkguqm1wpzkEUu-RglTsP_fPC4YuZeaxc29rO9Qs0Mo8WtGQRVCuwCj1icI2ZBz-z4c1QMIMqMzWDETMYMYMq86HKLOPq3vqPRTlz9dfi2k0E9teAxcq2TbBd5fGLKzQUOh9uOFpxr751b98-wBxPbv7n1_EdE9JVgscXt_xMiP6NkIXk5uHqzFzd_vszHt8-mPPiHc-vkfo</recordid><startdate>200209</startdate><enddate>200209</enddate><creator>Leentjens, A. F. G.</creator><creator>Lousberg, R.</creator><creator>Verhey, F. R. 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Prion diseases</topic><topic>Depression</topic><topic>depressive disorder</topic><topic>Depressive Disorder - complications</topic><topic>Depressive Disorder - diagnosis</topic><topic>Depressive Disorder - psychology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mood disorders</topic><topic>Neurology</topic><topic>Parkinson Disease - complications</topic><topic>Parkinson Disease - psychology</topic><topic>Parkinson's disease</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>risk factor</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leentjens, A. F. G.</creatorcontrib><creatorcontrib>Lousberg, R.</creatorcontrib><creatorcontrib>Verhey, F. R. J.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta psychiatrica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leentjens, A. F. G.</au><au>Lousberg, R.</au><au>Verhey, F. R. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Markers for depression in Parkinson's disease</atitle><jtitle>Acta psychiatrica Scandinavica</jtitle><addtitle>Acta Psychiatr Scand</addtitle><date>2002-09</date><risdate>2002</risdate><volume>106</volume><issue>3</issue><spage>196</spage><epage>201</epage><pages>196-201</pages><issn>0001-690X</issn><eissn>1600-0447</eissn><coden>APYSA9</coden><abstract>Leentjens AFG, Lousberg R, Verhey FRJ. Markers for depression in Parkinson's disease. Acta Psychiatr Scand 2002: 106: 196–201. © Blackwell Munksgaard 2002.
Objective: To assess whether general risk factors for depression are also markers of depression in patients with Parkinson's disease (PD) and to identify additional disease‐specific markers.
Method: A two‐step logistic regression was performed on data from 161 consecutively referred PD patients, 40 of whom suffered from major depressive disorder. A first logistic model was created with five general risk factors for depression. Next, five potential disease‐specific markers were added to see whether this would improve the model.
Results: The logistic model of general risk factors for depression also predicted depression in PD patients. A family history of depression was the most important marker. `Right‐sided onset' was the only disease‐specific marker that improved the model.
Conclusion: Established risk factors for depression in the general population are also markers of depression in PD. The importance of correcting for general risk factors for depression in the search for disease‐specific risk factors is stressed.</abstract><cop>Oxford UK</cop><pub>Munksgaard International Publishers</pub><pmid>12197857</pmid><doi>10.1034/j.1600-0447.2002.02045.x</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult and adolescent clinical studies Aged Biological and medical sciences Biomarkers Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Depression depressive disorder Depressive Disorder - complications Depressive Disorder - diagnosis Depressive Disorder - psychology Female Humans Male Medical sciences Mood disorders Neurology Parkinson Disease - complications Parkinson Disease - psychology Parkinson's disease Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry risk factor Risk Factors |
| title | Markers for depression in Parkinson's disease |
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