Sex ratios and the risks of haematological malignancies

Although the sex of an individual confers one of the greatest of the known risks for contracting leukaemia and lymphomas, very little attention is paid to these risks. It is the purpose of this paper to stimulate further research in this area. The sex rate ratios are presented for the commoner haema...

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Bibliographic Details
Published in:British journal of haematology 2002-09, Vol.118 (4), p.1071-1077
Main Authors: Cartwright, Ray A., Gurney, Karen A., Moorman, Anthony V.
Format: Article
Language:English
Subjects:
Acute Disease
Adolescent
Adult
Age Distribution
Aged
Aged, 80 and over
Biological and medical sciences
Child
Child, Preschool
Female
gender
Hematologic and hematopoietic diseases
Hematologic Neoplasms - epidemiology
Hodgkin Disease - epidemiology
Humans
Incidence
Infant
Infant, Newborn
leukaemias
Leukemia, Lymphocytic, Chronic, B-Cell - epidemiology
Leukemia, Myeloid - epidemiology
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lymphoma, Non-Hodgkin - epidemiology
lymphomas
Male
Medical sciences
Middle Aged
Multiple Myeloma - epidemiology
myelodysplastic syndrome
Myelodysplastic Syndromes - epidemiology
Myeloproliferative Disorders - epidemiology
Precursor Cell Lymphoblastic Leukemia-Lymphoma - epidemiology
Risk
Sex
Sex Distribution
sex ratio
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Summary:Although the sex of an individual confers one of the greatest of the known risks for contracting leukaemia and lymphomas, very little attention is paid to these risks. It is the purpose of this paper to stimulate further research in this area. The sex rate ratios are presented for the commoner haematological malignancies. The male excess in the lymphoid cancers is most marked in the youngest age group in non‐Hodgkin's lymphoma and Hodgkin's disease, while acute lymphoblastic leukaemia shows equal sex ratios in the childhood peak. Both chronic lymphocytic leukaemia and lymphocytic lymphoma display an unusual pattern, hitherto undescribed, with a large male excess specific to the 40s and 60s age groups. The myeloid sex ratios are all characterized by slight female excess in early adulthood followed by marked male excess. The reasons for these patterns are discussed.
ISSN:0007-1048
1365-2141
DOI:10.1046/j.1365-2141.2002.03750.x