Plasma kinetics of a chylomicron-like emulsion in normolipidemic obese women after a short-period weight loss by energy-restricted diet

Chylomicrons carry dietary fats in the bloodstream for storage in body tissues, and thus play an important role in obesity. The 2-step chylomicron metabolism consists of lipolysis by lipoprotein lipase (LPL) on vessel walls and hepatic uptake of triglyceride-depleted remnants. A triglyceride-rich em...

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Bibliographic Details
Published in:Metabolism, clinical and experimental clinical and experimental, 2002-09, Vol.51 (9), p.1097-1103
Main Authors: Oliveira, M.R.M., Maranh[atilde]o, R.C.
Format: Article
Language:English
Subjects:
Adult
Anthropometry
Apolipoproteins - blood
Biological and medical sciences
Blood Glucose - analysis
Chylomicrons - blood
Diet
Diet, Fat-Restricted
Dietary Carbohydrates - administration & dosage
Emulsions
Female
Humans
Kinetics
Lipids - blood
Medical sciences
Metabolic diseases
Obesity
Obesity - blood
Obesity - diet therapy
Obesity - pathology
Reference Values
Time Factors
Weight Loss
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Summary:Chylomicrons carry dietary fats in the bloodstream for storage in body tissues, and thus play an important role in obesity. The 2-step chylomicron metabolism consists of lipolysis by lipoprotein lipase (LPL) on vessel walls and hepatic uptake of triglyceride-depleted remnants. A triglyceride-rich emulsion that mimics chylomicrons, labeled with [9,10-3H]glycerol-trioleate (TG) and [1-14C] cholesteryl-oleate (CE) was intravenously injected into 14 obese women with body mass index between 30 and 40 kg/m2 (age, 30 to 40 years), before and after a 2-month energy-restricted diet and into non-obese controls for determination of radioactive lipid plasma kinetics. TG kinetics evaluates lipolysis, whereas CE kinetics evaluates remnant removal. The emulsion TG fractional clearance rate (FCR, in min[minus ]1) was similar in obese women and their controls (0.126 [plusmn] 0.065; controls, 0.111 [plusmn] 0.031), but the CE-FCR was pronouncedly reduced in the obese subjects (0.028 [plusmn] 0.014; controls, 0.070 [plusmn] 0.009 min[minus ]1; P [lt ] .0001). After the energy-restricted diet, TG-FCR was reduced in the obese women (0.075 [plusmn] 0.044 min[minus ]1; P [lt ] .05), but CE-FCR was unchanged (0.032 [plusmn] 0.025 min[minus ]1). Therefore, the lipolysis of the chylomicron-like emulsion is normal in obese women, but remnant removal from the plasma is diminished. After active weight loss by an energy-restricted diet, the remnant removal was unchanged but lipolysis was diminished, possibly due to adaptative changes in LPL activity.
ISSN:0026-0495
1532-8600
DOI:10.1053/meta.2002.34698