Copper-Catalyzed Oxidative Heterocyclization by Atmospheric Oxygen

Starting from Schiff bases 1, a wide variety of heterobicycles, which can be applied as pharmaceuticals or as ligands for catalysts, is accessible by copper‐catalyzed oxidation with atmospheric oxygen. The scheme shows, for example, the synthesis of imidazo[1,5‐a]pyridines 2 (R1=2‐hydroxy‐3‐methoxyp...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2002-08, Vol.41 (16), p.2962-2965
Main Authors: Bluhm, Martin E., Ciesielski, Michael, Görls, Helmar, Döring, Manfred
Format: Article
Language:English
Subjects:
copper
homogeneous catalysis
metalloenzymes
oxygen
Schiff bases
Online Access:Get full text
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Summary:Starting from Schiff bases 1, a wide variety of heterobicycles, which can be applied as pharmaceuticals or as ligands for catalysts, is accessible by copper‐catalyzed oxidation with atmospheric oxygen. The scheme shows, for example, the synthesis of imidazo[1,5‐a]pyridines 2 (R1=2‐hydroxy‐3‐methoxyphenyl, tBu, 2‐hydroxyphenyl, 2‐aminophenyl; R2=2‐pyridyl, Me, phenyl).
ISSN:1433-7851
1521-3773
DOI:10.1002/1521-3773(20020816)41:16<2962::AID-ANIE2962>3.0.CO;2-6