Leukocyte–endothelial cell adhesion molecule 1 (LECAM-1) polymorphism is associated with diabetic nephropathy in type 2 diabetes mellitus

Background/aims: Glomerular infiltration with monocytes/macrophages has been implicated in the pathogenesis of diabetic nephropathy. In this study, we evaluated the relationship between the genetic polymorphism in leukocyte–endothelial adhesion molecule-1 (LECAM-1) and diabetic nephropathy in patien...

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Bibliographic Details
Published in:Journal of diabetes and its complications 2002-09, Vol.16 (5), p.333-337
Main Authors: Kamiuchi, Kenji, Hasegawa, Goji, Obayashi, Hiroshi, Kitamura, Akane, Ishii, Michiyo, Yano, Miho, Kanatsuna, Takahiro, Yoshikawa, Toshikazu, Nakamura, Naoto
Format: Article
Language:English
Subjects:
Adhesion molecule
Aged
Associated diseases and complications
Base Sequence
Biological and medical sciences
Diabetes Mellitus, Type 2 - genetics
Diabetes. Impaired glucose tolerance
Diabetic nephropathy
Diabetic Neuropathies - genetics
DNA - blood
DNA - genetics
DNA Primers
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Female
Gene Frequency
Genotype
Humans
L-Selectin - genetics
LECAM-1
Male
Medical sciences
Middle Aged
Polymerase Chain Reaction
Polymorphism
Polymorphism, Genetic
Polymorphism, Restriction Fragment Length
Reference Values
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Summary:Background/aims: Glomerular infiltration with monocytes/macrophages has been implicated in the pathogenesis of diabetic nephropathy. In this study, we evaluated the relationship between the genetic polymorphism in leukocyte–endothelial adhesion molecule-1 (LECAM-1) and diabetic nephropathy in patients with type 2 diabetes mellitus. Methods: We determined the frequency of the LECAM-1 P213S genotype in 102 diabetic patients with diabetic nephropathy, 90 diabetic patients with no evidence of diabetic nephropathy, and 200 healthy control individuals. Results: The frequency of the LECAM-1 213PP genotype and P allele in patients with diabetic nephropathy was significantly higher than that in patients without nephropathy (genotype 68% vs. 53%, χ 2=6.78, P=.034; allele 83% vs. 72%, χ 2=6.26, P=.012). The LECAM-1 P213 genotype was associated with a 1.86-fold increased risk for nephropathy independently of other risk factors. Conclusion: The data suggest that the LECAM-1 213PP genotype is a genetic risk factor for the development of nephropathy in type 2 diabetes mellitus.
ISSN:1056-8727
1873-460X
DOI:10.1016/S1056-8727(01)00226-4