High and low hemoglobin glycation phenotypes in type 1 diabetes: A challenge for interpretation of glycemic control

This study tested the hypothesis that there are consistent individual differences in the relationship between glycated hemoglobin (HbA1c) and mean blood glucose (MBG) levels in individuals with similar preceding blood glucose levels. Blood glucose data were collected for up to 2.3 years by 128 child...

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Bibliographic Details
Published in:Journal of diabetes and its complications 2002-09, Vol.16 (5), p.313-320
Main Authors: Hempe, James M., Gomez, Ricardo, McCarter, Robert J., Chalew, Stuart A.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Biomarkers - blood
Blood Glucose - metabolism
Child
Child, Preschool
Diabetes
Diabetes Mellitus, Type 1 - blood
Diabetes Mellitus, Type 1 - genetics
Diabetes. Impaired glucose tolerance
Diabetic complications
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Erythrocyte Aging
Erythrocytes - physiology
Glycated hemoglobin
Glycated Hemoglobin A - genetics
Glycemic control
HbA1c
Humans
Infant
Management. Various non-drug treatments. Langerhans islet grafts
Medical sciences
Phenotype
Regression Analysis
Citations: Items that cite this one
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Summary:This study tested the hypothesis that there are consistent individual differences in the relationship between glycated hemoglobin (HbA1c) and mean blood glucose (MBG) levels in individuals with similar preceding blood glucose levels. Blood glucose data were collected for up to 2.3 years by 128 children and adolescents with type 1 diabetes. HbA1c values were date-matched with MBG levels calculated from an average of 85 self-monitored blood glucose measurements collected in the previous 30 days. There was significant linear correlation between MBG and HbA1c (HbA1c=0.027×MBG+5.8, n=682, r=.71, P
ISSN:1056-8727
1873-460X
DOI:10.1016/S1056-8727(01)00227-6