Higher cortisol:cortisone ratios in the preovulatory follicle of completely unstimulated IVF cycles indicate oocytes with increased pregnancy potential

BACKGROUND: Conception following gonadotrophin-stimulated IVF and embryo transfer has been associated with a higher intrafollicular cortisol:cortisone ratio and decreased metabolism of cortisol to cortisone. The role of glucocorticoids in human oocyte maturation is not fully understood, but active g...

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Bibliographic Details
Published in:Human reproduction (Oxford) 2002-09, Vol.17 (9), p.2410-2414
Main Authors: Keay, S.D., Harlow, C.R., Wood, P.J., Jenkins, J.M., Cahill, D.J.
Format: Article
Language:English
Subjects:
11β-HSD
Adult
Biological and medical sciences
Birth control
cortisol
cortisone
Cortisone - metabolism
Embryo Implantation
Female
Fertilization
Fertilization in Vitro
Follicular Phase - metabolism
Gynecology. Andrology. Obstetrics
Humans
Hydrocortisone - metabolism
Medical sciences
natural cycle IVF
Oocytes - physiology
Ovarian Follicle - metabolism
Pregnancy
Sterility. Assisted procreation
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Summary:BACKGROUND: Conception following gonadotrophin-stimulated IVF and embryo transfer has been associated with a higher intrafollicular cortisol:cortisone ratio and decreased metabolism of cortisol to cortisone. The role of glucocorticoids in human oocyte maturation is not fully understood, but active glucocorticoid (cortisol) may be important. This study relates intrafollicular cortisol and cortisone concentrations to oocyte fertilization and embryo implantation in unstimulated cycles. METHODS: Patients aged
ISSN:0268-1161
1460-2350
1460-2350
DOI:10.1093/humrep/17.9.2410