Determination of pentoxifylline in serum by high-performance thin-layer chromatography

An analytical method to study the bioavailability of newly developed pentoxifylline sustained-release tablets has been developed and assessed in experiments on dogs. For the isolation of pentoxifylline and its metabolites from serum solid—liquid extraction was applied by involving the internal stand...

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Bibliographic Details
Published in:Journal of pharmaceutical and biomedical analysis 1991, Vol.9 (3), p.247-250
Main Authors: BAUEROVA, K, SOLTES, L, KALLAY, Z, SCHMIDTOVA, K
Format: Article
Language:English
Subjects:
Administration, Oral
Analysis
Animals
bioavailability
Biological and medical sciences
Biological Availability
Chromatography, Thin Layer
Delayed-Action Preparations
Dogs
General pharmacology
Half-Life
high-performance thin-layer chromatography
Injections, Intravenous
Medical sciences
Pentoxifylline
Pentoxifylline - administration & dosage
Pentoxifylline - blood
Pentoxifylline - pharmacokinetics
Pharmacology. Drug treatments
sustained-release dosage form
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Summary:An analytical method to study the bioavailability of newly developed pentoxifylline sustained-release tablets has been developed and assessed in experiments on dogs. For the isolation of pentoxifylline and its metabolites from serum solid—liquid extraction was applied by involving the internal standard probe. HPTLC plates with a preconcentration zone were used for separation of the analysed substances, using chloroform—methanol (95:5, v/v). Quantification was by densitometric detection. The detector response was linear in the concentration range investigated for pentoxifylline: 0.02–1.5 μg ml −1 of serum.
ISSN:0731-7085
1873-264X
DOI:10.1016/0731-7085(91)80153-Z