Adrenergic regulation of bone metabolism: Possible involvement of sympathetic innervation of osteoblastic and osteoclastic cells

It has been demonstrated that human osteoblastic as well as osteoclastic cells are equipped with adrenergic receptors and neuropeptide receptors and that they constitutively express diffusible axon guidance molecules that are known to function as a chemoattractant and/or chemorepellent for growing n...

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Bibliographic Details
Published in:Microscopy research and technique 2002-07, Vol.58 (2), p.77-84
Main Author: Togari, Akifumi
Format: Article
Language:English
Subjects:
adrenergic receptor
axon guidance molecule
Axons - physiology
Bone and Bones - physiology
Bone Resorption
Epinephrine - metabolism
Humans
neuropeptide receptor
Osteoblasts - physiology
osteoclastogenesis
Osteoclasts - physiology
Receptors, Adrenergic - metabolism
Receptors, Neuropeptide - metabolism
Sympathetic Nervous System - physiology
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Summary:It has been demonstrated that human osteoblastic as well as osteoclastic cells are equipped with adrenergic receptors and neuropeptide receptors and that they constitutively express diffusible axon guidance molecules that are known to function as a chemoattractant and/or chemorepellent for growing nerve fibers. These findings suggest that the extension of axons of sympathetic and peripheral sensory neurons to osteoblastic and osteoclastic cells is required for the dynamic neural regulation of local bone metabolism. Recently, bone resorption modulated by sympathetic stimulation was demonstrated to be associated with ODF (osteoclast differentiation factor) and OCIF (osteoclastogenesis inhibitory factor) produced by osteoblasts/stromal cells. This review summarizes the evidence implicating sympathetic neuron action in bone metabolism. The possible function of osteoclastogenesis, which could result in the initiation of sympathomimetic bone resorption, is also discussed. Microsc. Res. Tech. 58:77–84, 2002. © 2002 Wiley‐Liss, Inc.
ISSN:1059-910X
1097-0029
DOI:10.1002/jemt.10121