Progenitor cells of the olfactory receptor neuron lineage

The olfactory epithelium of the mouse has many properties that make it an ideal system for studying the molecular regulation of neurogenesis. We have used a combination of in vitro and in vivo approaches to identify three distinct stages of neuronal progenitors in the olfactory receptor neuron linea...

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Bibliographic Details
Published in:Microscopy research and technique 2002-08, Vol.58 (3), p.176-188
Main Authors: Calof, Anne L., Bonnin, Alexandre, Crocker, Candice, Kawauchi, Shimako, Murray, Richard C., Shou, Jianyong, Wu, Hsiao-Huei
Format: Article
Language:English
Subjects:
Animals
bone morphogenetic proteins
Cells, Cultured
fibroblast growth factors
In Vitro Techniques
Mice
neurogenesis
Olfactory Mucosa - cytology
Olfactory Receptor Neurons - cytology
stem cell
Stem Cells - physiology
transcription factors
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Summary:The olfactory epithelium of the mouse has many properties that make it an ideal system for studying the molecular regulation of neurogenesis. We have used a combination of in vitro and in vivo approaches to identify three distinct stages of neuronal progenitors in the olfactory receptor neuron lineage. The neuronal stem cell, which is ultimately responsible for continual neuron renewal in this system, gives rise to a transit amplifying progenitor identified by its expression of a transcription factor, MASH1. The MASH1‐expressing progenitor gives rise to a second transit amplifying progenitor, the Immediate Neuronal Precursor, which is distinct from the stem cell and MASH1‐expressing progenitor, and gives rise quantitatively to olfactory receptor neurons. Regulation of progenitor cell proliferation and differentiation occurs at each of these three cell stages, and growth factors of the fibroblast growth factor (FGF) and bone morphogenetic protein (BMP) families appear to play particularly important roles in these processes. Analyses of the actions of FGFs and BMPs reveal that negative signaling plays at least as important a role as positive signaling in the regulation of olfactory neurogenesis. Microsc. Res. Tech. 58:176–188, 2002. © 2002 Wiley‐Liss, Inc.
ISSN:1059-910X
1097-0029
DOI:10.1002/jemt.10147