Short-term prophylaxis with deoxyspergualin prevents testicular autoimmunity in mice

The effects of the treatment with the immunosuppressant deoxyspergualin on the development of experimental autoimmune orchitis were studied. The results showed that C3H/He mice immunized with testicular germ cells and treated daily with either 0.3 or 3 mg/kg body weight deoxyspergualin during days 1...

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Bibliographic Details
Published in:European journal of pharmacology 2002-08, Vol.450 (2), p.209-212
Main Authors: Ablake, Maira, Itoh, Masahiro, Kaneko, Tetsushi, Iimura, Akira, Nakamura, Yoichi, Meroni, Pierluigi, Nicoletti, Ferdinando
Format: Article
Language:English
Subjects:
Animals
Autoimmune Diseases - immunology
Autoimmune Diseases - pathology
Autoimmune Diseases - prevention & control
Autoimmunity
Biological and medical sciences
Deoxyspergualin
Dose-Response Relationship, Drug
Guanidines - administration & dosage
Guanidines - pharmacology
Hypersensitivity, Delayed - immunology
Hypersensitivity, Delayed - prevention & control
Immunomodulators
Immunosuppressive Agents - administration & dosage
Immunosuppressive Agents - pharmacology
Immunotherapy
Male
Medical sciences
Mice
Mice, Inbred C3H
Orchitis
Orchitis - immunology
Orchitis - pathology
Orchitis - prevention & control
Pharmacology. Drug treatments
Time Factors
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Summary:The effects of the treatment with the immunosuppressant deoxyspergualin on the development of experimental autoimmune orchitis were studied. The results showed that C3H/He mice immunized with testicular germ cells and treated daily with either 0.3 or 3 mg/kg body weight deoxyspergualin during days 15–20 post-immunization developed experimental autoimmune orchitis lesions with a significantly lower incidence and severity than did the control mice treated under the same experimental conditions with phosphate buffered saline (PBS). The effects of deoxyspergualin were clearly dose-dependent, and the higher dose of the drug also markedly reduced the degree of delayed type hypersensitivity responses against testicular germ cells. These data suggest that deoxyspergualin may be worthy of consideration for the prevention/treatment of human immunoinflammatory orchitis.
ISSN:0014-2999
1879-0712
DOI:10.1016/S0014-2999(02)02045-9