Initiation of humoral immunity. II. The effects of T-independent and T-dependent antigens on the distribution of lymphocyte populations

The effect of injecting T-independent (lipopolysaccharide, LPS) and T-dependent (bovine serum albumin, BSA) antigens on the redistribution of lymphocyte populations in immature male chickens was investigated. In the blood, percentages of total T-cells (CD3+), T-helper cells (CD4+), and T-cytotoxic/s...

Full description

Saved in:
Bibliographic Details
Published in:Developmental and comparative immunology 2002-10, Vol.26 (8), p.761-771
Main Authors: Gehad, A.E, Lillehoj, H.S, Hendricks, G.L, Mashaly, M.M
Format: Article
Language:English
Subjects:
Animals
Antibodies - immunology
Antigens
Antigens - immunology
Blood Platelets - immunology
CD3 Complex - analysis
CD4 Antigens - analysis
CD8 Antigens - analysis
Cell Count
Chicken
Chickens - blood
Chickens - immunology
Lipopolysaccharides - administration & dosage
Lipopolysaccharides - immunology
Lymphocyte Subsets - immunology
Lymphocytes
Macrophages - immunology
Male
Monocytes - immunology
Serum Albumin, Bovine - administration & dosage
Serum Albumin, Bovine - immunology
Spleen - immunology
Time Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The effect of injecting T-independent (lipopolysaccharide, LPS) and T-dependent (bovine serum albumin, BSA) antigens on the redistribution of lymphocyte populations in immature male chickens was investigated. In the blood, percentages of total T-cells (CD3+), T-helper cells (CD4+), and T-cytotoxic/suppressor cells (CD8+) significantly decreased post-LPS injection (PLI) but not post-BSA injection (PBI), while percentages of monocytes/thrombocytes (K1+) significantly increased PLI. Interleukin-1 receptor expression on blood lymphocytes increased significantly PLI and PBI. In the spleen, the percentages of total T-cells (CD3+) increased significantly PLI and PBI, macrophage (K1+) percentages increased significantly PLI, while B-cell percentages decreased significantly PLI. These results indicate that following antigen injection, there is a redistribution of peripheral blood lymphocytes (specifically T-lymphocytes) to secondary lymphoid organs and the kinetics and magnitude of the changes can differ according to the type of antigen used.
ISSN:0145-305X
1879-0089
DOI:10.1016/S0145-305X(02)00021-6