Nanoparticles in cancer therapy and diagnosis

Numerous investigations have shown that both tissue and cell distribution profiles of anticancer drugs can be controlled by their entrapment in submicronic colloidal systems (nanoparticles). The rationale behind this approach is to increase antitumor efficacy, while reducing systemic side-effects. T...

Full description

Saved in:
Bibliographic Details
Published in:Advanced drug delivery reviews 2002-09, Vol.54 (5), p.631-651
Main Authors: Brigger, Irène, Dubernet, Catherine, Couvreur, Patrick
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - administration & dosage
Biomarkers, Tumor - analysis
Conventional or long-circulating carriers
Drug Administration Routes
Drug Carriers
Drug Delivery Systems
Drug Resistance, Multiple
EPR effect
Humans
Magnetic Resonance Imaging
Multidrug resistance (MDR)
Nanocapsules
Nanoparticles
Nanospheres
Nanotechnology
Neoplasms - diagnosis
Neoplasms - diagnostic imaging
Neoplasms - drug therapy
Oligonucleotide delivery
Oligonucleotides, Antisense - administration & dosage
Particle Size
Passive or active tumor targeting
Radionuclide Imaging
Tumor Cells, Cultured
Tumor imaging
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Numerous investigations have shown that both tissue and cell distribution profiles of anticancer drugs can be controlled by their entrapment in submicronic colloidal systems (nanoparticles). The rationale behind this approach is to increase antitumor efficacy, while reducing systemic side-effects. This review provides an update of tumor targeting with conventional or long-circulating nanoparticles. The in vivo fate of these systems, after intravascular or tumoral administration, is discussed, as well as the mechanism involved in tumor regression. Nanoparticles are also of benefit for the selective delivery of oligonucleotides to tumor cells. Moreover, certain types of nanoparticles showed some interesting capacity to reverse MDR resistance, which is a major problem in chemotherapy. The first experiments, aiming to decorate nanoparticles with molecular ligand for ‘active’ targeting of cancerous cells, are also discussed here. The last part of this review focus on the application of nanoparticles in imaging for cancer diagnosis.
ISSN:0169-409X
1872-8294
DOI:10.1016/S0169-409X(02)00044-3