Selective loss of cholinergic sudomotor fibers causes anhidrosis in Ross syndrome

Ross syndrome consists of segmental hyperhidrosis with widespread anhidrosis, Adie syndrome, and areflexia. The cause of this disorder is unknown. Selective degeneration of cholinergic fibers or of neural crest–derived structures has been suggested. We present clinical and skin biopsy data of 4 pati...

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Bibliographic Details
Published in:Annals of neurology 2002-08, Vol.52 (2), p.247-250
Main Authors: Sommer, Claudia, Lindenlaub, Thies, Zillikens, Detlef, Toyka, Klaus V., Naumann, Markus
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Biopsy
Cholinergic Fibers - pathology
Dermatology
Female
Humans
Hyperhidrosis - complications
Hypohidrosis - etiology
Hypohidrosis - pathology
Male
Medical sciences
Middle Aged
Pupil Disorders - complications
Reflex, Abnormal
Skin - pathology
Skin involvement in other diseases. Miscellaneous. General aspects
Sweat Glands - innervation
Syndrome
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Summary:Ross syndrome consists of segmental hyperhidrosis with widespread anhidrosis, Adie syndrome, and areflexia. The cause of this disorder is unknown. Selective degeneration of cholinergic fibers or of neural crest–derived structures has been suggested. We present clinical and skin biopsy data of 4 patients, providing evidence of reduced cholinergic sweat gland innervation in hypohidrotic skin by morphometric analysis. These findings indicate a selective degenerative process of the cholinergic sudomotor neurons.
ISSN:0364-5134
1531-8249
DOI:10.1002/ana.10256