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Selective loss of cholinergic sudomotor fibers causes anhidrosis in Ross syndrome
Ross syndrome consists of segmental hyperhidrosis with widespread anhidrosis, Adie syndrome, and areflexia. The cause of this disorder is unknown. Selective degeneration of cholinergic fibers or of neural crest–derived structures has been suggested. We present clinical and skin biopsy data of 4 pati...
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| Published in: | Annals of neurology 2002-08, Vol.52 (2), p.247-250 |
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| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c4556-a96c8bc7453e15c557a5a577db4e8a6df60372d7e9bba4275378491c63bdb16f3 |
| container_end_page | 250 |
| container_issue | 2 |
| container_start_page | 247 |
| container_title | Annals of neurology |
| container_volume | 52 |
| creator | Sommer, Claudia Lindenlaub, Thies Zillikens, Detlef Toyka, Klaus V. Naumann, Markus |
| description | Ross syndrome consists of segmental hyperhidrosis with widespread anhidrosis, Adie syndrome, and areflexia. The cause of this disorder is unknown. Selective degeneration of cholinergic fibers or of neural crest–derived structures has been suggested. We present clinical and skin biopsy data of 4 patients, providing evidence of reduced cholinergic sweat gland innervation in hypohidrotic skin by morphometric analysis. These findings indicate a selective degenerative process of the cholinergic sudomotor neurons. |
| doi_str_mv | 10.1002/ana.10256 |
| format | article |
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The cause of this disorder is unknown. Selective degeneration of cholinergic fibers or of neural crest–derived structures has been suggested. We present clinical and skin biopsy data of 4 patients, providing evidence of reduced cholinergic sweat gland innervation in hypohidrotic skin by morphometric analysis. These findings indicate a selective degenerative process of the cholinergic sudomotor neurons.</description><identifier>ISSN: 0364-5134</identifier><identifier>EISSN: 1531-8249</identifier><identifier>DOI: 10.1002/ana.10256</identifier><identifier>PMID: 12210801</identifier><identifier>CODEN: ANNED3</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Biological and medical sciences ; Biopsy ; Cholinergic Fibers - pathology ; Dermatology ; Female ; Humans ; Hyperhidrosis - complications ; Hypohidrosis - etiology ; Hypohidrosis - pathology ; Male ; Medical sciences ; Middle Aged ; Pupil Disorders - complications ; Reflex, Abnormal ; Skin - pathology ; Skin involvement in other diseases. Miscellaneous. 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The cause of this disorder is unknown. Selective degeneration of cholinergic fibers or of neural crest–derived structures has been suggested. We present clinical and skin biopsy data of 4 patients, providing evidence of reduced cholinergic sweat gland innervation in hypohidrotic skin by morphometric analysis. These findings indicate a selective degenerative process of the cholinergic sudomotor neurons.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Cholinergic Fibers - pathology</subject><subject>Dermatology</subject><subject>Female</subject><subject>Humans</subject><subject>Hyperhidrosis - complications</subject><subject>Hypohidrosis - etiology</subject><subject>Hypohidrosis - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pupil Disorders - complications</subject><subject>Reflex, Abnormal</subject><subject>Skin - pathology</subject><subject>Skin involvement in other diseases. Miscellaneous. General aspects</subject><subject>Sweat Glands - innervation</subject><subject>Syndrome</subject><issn>0364-5134</issn><issn>1531-8249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><recordid>eNp1kE9v1DAQxS0EokvhwBdAvoDEIdT_nRxXKyhVyyIoqNwsx5lQQxIXzwbYb1-X3bYnTjMa_d57o0fIc87ecMbEkZ98WYQ2D8iCa8mrWqjmIVkwaVSluVQH5AniD8ZYYzh7TA64EJzVjC_Ip3MYIGzib6BDQqSpp-EyDXGC_D0GinOXxrRJmfaxhYw0-BkBqZ8uY5cTRqRxop9vlLidymWEp-RR7weEZ_t5SL6-e_tl9b46-3h8slqeVUFpbSrfmFC3wSotgeugtfXaa2u7VkHtTdcbJq3oLDRt65WwWtpaNTwY2XYtN708JK92vlc5_ZoBN26MGGAY_ARpRmcFU3XTyAK-3oGhPIwZeneV4-jz1nHmbvpzpT_3r7_Cvtibzu0I3T25L6wAL_eAx-CHPvspRLznZC21bkThjnbcnzjA9v-Jbrle3kZXO0XEDfy9U_j80xkrrXYX62O3Pr_4cPptdVqCrgHBeZYs</recordid><startdate>200208</startdate><enddate>200208</enddate><creator>Sommer, Claudia</creator><creator>Lindenlaub, Thies</creator><creator>Zillikens, Detlef</creator><creator>Toyka, Klaus V.</creator><creator>Naumann, Markus</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Willey-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200208</creationdate><title>Selective loss of cholinergic sudomotor fibers causes anhidrosis in Ross syndrome</title><author>Sommer, Claudia ; Lindenlaub, Thies ; Zillikens, Detlef ; Toyka, Klaus V. ; Naumann, Markus</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4556-a96c8bc7453e15c557a5a577db4e8a6df60372d7e9bba4275378491c63bdb16f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Cholinergic Fibers - pathology</topic><topic>Dermatology</topic><topic>Female</topic><topic>Humans</topic><topic>Hyperhidrosis - complications</topic><topic>Hypohidrosis - etiology</topic><topic>Hypohidrosis - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pupil Disorders - complications</topic><topic>Reflex, Abnormal</topic><topic>Skin - pathology</topic><topic>Skin involvement in other diseases. Miscellaneous. General aspects</topic><topic>Sweat Glands - innervation</topic><topic>Syndrome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sommer, Claudia</creatorcontrib><creatorcontrib>Lindenlaub, Thies</creatorcontrib><creatorcontrib>Zillikens, Detlef</creatorcontrib><creatorcontrib>Toyka, Klaus V.</creatorcontrib><creatorcontrib>Naumann, Markus</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sommer, Claudia</au><au>Lindenlaub, Thies</au><au>Zillikens, Detlef</au><au>Toyka, Klaus V.</au><au>Naumann, Markus</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Selective loss of cholinergic sudomotor fibers causes anhidrosis in Ross syndrome</atitle><jtitle>Annals of neurology</jtitle><addtitle>Ann Neurol</addtitle><date>2002-08</date><risdate>2002</risdate><volume>52</volume><issue>2</issue><spage>247</spage><epage>250</epage><pages>247-250</pages><issn>0364-5134</issn><eissn>1531-8249</eissn><coden>ANNED3</coden><abstract>Ross syndrome consists of segmental hyperhidrosis with widespread anhidrosis, Adie syndrome, and areflexia. The cause of this disorder is unknown. Selective degeneration of cholinergic fibers or of neural crest–derived structures has been suggested. We present clinical and skin biopsy data of 4 patients, providing evidence of reduced cholinergic sweat gland innervation in hypohidrotic skin by morphometric analysis. These findings indicate a selective degenerative process of the cholinergic sudomotor neurons.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>12210801</pmid><doi>10.1002/ana.10256</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0364-5134 |
| ispartof | Annals of neurology, 2002-08, Vol.52 (2), p.247-250 |
| issn | 0364-5134 1531-8249 |
| language | eng |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Adult Biological and medical sciences Biopsy Cholinergic Fibers - pathology Dermatology Female Humans Hyperhidrosis - complications Hypohidrosis - etiology Hypohidrosis - pathology Male Medical sciences Middle Aged Pupil Disorders - complications Reflex, Abnormal Skin - pathology Skin involvement in other diseases. Miscellaneous. General aspects Sweat Glands - innervation Syndrome |
| title | Selective loss of cholinergic sudomotor fibers causes anhidrosis in Ross syndrome |
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