Immunomodulating activities of soluble synthetic polymer-bound drugs

The introduction of a synthetic material into the body always affects different body systems, including the defense system. Synthetic polymers are usually thymus-independent antigens with only a limited ability to elicit antibody formation or to induce a cellular immune response against them. Howeve...

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Bibliographic Details
Published in:Advanced drug delivery reviews 2002-09, Vol.54 (5), p.653-674
Main Author: Rihova, Blanka
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic - administration & dosage
Adjuvants, Immunologic - chemistry
Adjuvants, Immunologic - pharmacology
Animals
Anti-cancer immunity
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - pharmacology
Doxorubicin - administration & dosage
Doxorubicin - pharmacology
Drug Carriers
Drug delivery
Fas Ligand Protein
Fas-counterattack
Humans
Immunogenicity
Immunomobilization
Immunomodulation
Killer Cells, Natural - drug effects
Macrophages - drug effects
Membrane Glycoproteins - immunology
Methacrylates
N-(2-Hydroxypropyl)methacrylamide (HPMA)
Neoplasms - drug therapy
Neoplasms - immunology
Polymers - pharmacology
Solubility
Vaccination
Vaccines - administration & dosage
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Summary:The introduction of a synthetic material into the body always affects different body systems, including the defense system. Synthetic polymers are usually thymus-independent antigens with only a limited ability to elicit antibody formation or to induce a cellular immune response against them. However, there are many other ways that they influence or can be used to influence the immune system of the host. Low-immunogenic water-soluble synthetic polymers sometimes exhibit significant immunomodulating activity, mainly concerning the activation/suppression of NK cells, LAK cells and macrophages. Some of them, such as poly(ethylene glycol) and poly[ N-(2-hydroxypropyl)methacrylamide], can be used as effective protein carriers, as they are able to reduce the immunogenicity of conjugated proteins and/or to reduce non-specific uptake of liposome/nanoparticle-entrapped drugs and other therapeutic agents. Recently, the development of vaccine delivery systems prepared from biodegradable and biocompatible water-soluble synthetic polymers, microspheres, liposomes and/or nanoparticles has received considerable attention, as they can be tailored to meet the specific physical, chemical, and immunogenic requirements of a particular antigen and some of them can also act as adjuvants.
ISSN:0169-409X
1872-8294
DOI:10.1016/S0169-409X(02)00043-1