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Influence of age on clinical course, management and mortality of acute myocardial infarction in the Spanish population
Background: To assess age-related differences in cardiovascular risk factors, clinical course and management of patients with acute myocardial infarction (AMI) in intensive care (ICU) or coronary care units (CCU). Methods: A retrospective cohort study was conducted of all AMI patients listed in the...
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| Published in: | International journal of cardiology 2002-10, Vol.85 (2), p.285-296 |
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| container_issue | 2 |
| container_start_page | 285 |
| container_title | International journal of cardiology |
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| creator | Ruiz-Bailén, Manuel Aguayo de Hoyos, Eduardo Ramos-Cuadra, José Ángel Dı́az-Castellanos, Miguel Ángel Issa-Khozouz, Ziad Reina-Toral, Antonio López-Martı́nez, Asunción Calatrava-López, Jesús Laynez-Bretones, Francisco Castillo-Parra, Juan Carlos De La Torre-Prados, Marı́a Victoria |
| description | Background: To assess age-related differences in cardiovascular risk factors, clinical course and management of patients with acute myocardial infarction (AMI) in intensive care (ICU) or coronary care units (CCU).
Methods: A retrospective cohort study was conducted of all AMI patients listed in the ARIAM register (Analysis of Delay in AMI), a multi-centre register in which 119 Spanish hospitals participated. The study period was from January 1995 to January 2001. A univariate analysis was carried out to evaluate differences between different age groups. Multivariate analysis was used to assess whether age difference was an independent predisposing factor for mortality and for differences in patient management.
Results: 17,761 patients were admitted to the ICUs/CCUs with a diagnosis of AMI. The distribution by ages was: 84 years, 604 (3.4%) (
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| doi_str_mv | 10.1016/S0167-5273(02)00187-0 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72056555</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0167527302001870</els_id><sourcerecordid>72056555</sourcerecordid><originalsourceid>FETCH-LOGICAL-c443t-f66e3679274403a694f0aa276be7ad9dcf46d7339aa64ae9ba5c453ac174eb1c3</originalsourceid><addsrcrecordid>eNqFkU1rFTEUhoMo9tr6E5RsFAWnZiZfN6sipdVCwUXrOpybObGRmcyYZAr33zf3A7t0k3dxnvckPCHkXcvOW9aqr3f10I3sNP_Eus-MtWvdsBdkVVM0rZbiJVn9Q07Im5z_MMaEMevX5KTtOraWRq3I4030w4LRIZ08hd81InVDiMHBQN20pIxf6AixjkaMhULs6TilAkMo233HLQXpuJ0cpD7UUogekiuhLgqRlgekdzPEkB_oPM3LALvJGXnlYcj49pin5Nf11f3lj-b25_eby2-3jROCl8YrhVxp02khGAdlhGcAnVYb1NCb3nmhes25AVAC0GxAOiE5uFYL3LSOn5KPh71zmv4umIsdQ3Y4DBBxWrLVHZNKSllBeQBdmnJO6O2cwghpa1tmd8LtXrjd2bSss3vhltXe--MFy2bE_rl1NFyBD0cAclXqE0QX8jPH18Ywwyt3ceCw6ngMmGx2YfcvfUjoiu2n8J-nPAEml56-</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72056555</pqid></control><display><type>article</type><title>Influence of age on clinical course, management and mortality of acute myocardial infarction in the Spanish population</title><source>ScienceDirect Freedom Collection 2022-2024</source><creator>Ruiz-Bailén, Manuel ; Aguayo de Hoyos, Eduardo ; Ramos-Cuadra, José Ángel ; Dı́az-Castellanos, Miguel Ángel ; Issa-Khozouz, Ziad ; Reina-Toral, Antonio ; López-Martı́nez, Asunción ; Calatrava-López, Jesús ; Laynez-Bretones, Francisco ; Castillo-Parra, Juan Carlos ; De La Torre-Prados, Marı́a Victoria</creator><creatorcontrib>Ruiz-Bailén, Manuel ; Aguayo de Hoyos, Eduardo ; Ramos-Cuadra, José Ángel ; Dı́az-Castellanos, Miguel Ángel ; Issa-Khozouz, Ziad ; Reina-Toral, Antonio ; López-Martı́nez, Asunción ; Calatrava-López, Jesús ; Laynez-Bretones, Francisco ; Castillo-Parra, Juan Carlos ; De La Torre-Prados, Marı́a Victoria ; for the ARIAM Group ; ARIAM Group</creatorcontrib><description>Background: To assess age-related differences in cardiovascular risk factors, clinical course and management of patients with acute myocardial infarction (AMI) in intensive care (ICU) or coronary care units (CCU).
Methods: A retrospective cohort study was conducted of all AMI patients listed in the ARIAM register (Analysis of Delay in AMI), a multi-centre register in which 119 Spanish hospitals participated. The study period was from January 1995 to January 2001. A univariate analysis was carried out to evaluate differences between different age groups. Multivariate analysis was used to assess whether age difference was an independent predisposing factor for mortality and for differences in patient management.
Results: 17,761 patients were admitted to the ICUs/CCUs with a diagnosis of AMI. The distribution by ages was: <55 years, 3954 patients (22.3%); 55–64 years, 3593 (22.2%); 65–74 years, 5924 (33.4%); 75–84 years, 3686 (20.8%); and >84 years, 604 (3.4%) (
P<0.0001); 24.6% of the patients were female, and the relative proportion of females increased with age. There were clear differences in risk factors between the different age groups, with a predominance of tobacco, cholesterol and family history of heart disease in the younger patients. The incidence of complications, including haemorrhagic complications, increased significantly with age. The older age groups had a lower rate of thrombolysis and less use of revascularisation techniques. The mortality of the above groups was 2.6, 5.4, 10.7, 17.7 and 25.8%, respectively. Age difference was an independent predictive variable for mortality and the administration of thrombolysis.
Conclusions: The distinct age groups differed in cardiovascular risk factors, management and mortality. Age is a significant independent predictive variable for mortality and for the administration of thrombolysis.</description><identifier>ISSN: 0167-5273</identifier><identifier>EISSN: 1874-1754</identifier><identifier>DOI: 10.1016/S0167-5273(02)00187-0</identifier><identifier>PMID: 12208596</identifier><identifier>CODEN: IJCDD5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Acute myocardial infarction ; Adolescent ; Adult ; Age ; Age Factors ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Cardiology. Vascular system ; Child ; Cohort Studies ; Coronary heart disease ; Elderly ; Female ; Heart ; Humans ; Incidence ; Length of Stay ; Male ; Medical sciences ; Middle Aged ; Mortality ; Myocardial Infarction - complications ; Myocardial Infarction - mortality ; Myocardial Infarction - therapy ; Prognosis ; Retrospective Studies ; Risk Factors ; Spain ; Statistics as Topic ; Thrombolysis ; Thrombolytic Therapy - statistics & numerical data</subject><ispartof>International journal of cardiology, 2002-10, Vol.85 (2), p.285-296</ispartof><rights>2002 Elsevier Science Ireland Ltd</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c443t-f66e3679274403a694f0aa276be7ad9dcf46d7339aa64ae9ba5c453ac174eb1c3</citedby><cites>FETCH-LOGICAL-c443t-f66e3679274403a694f0aa276be7ad9dcf46d7339aa64ae9ba5c453ac174eb1c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13899093$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12208596$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ruiz-Bailén, Manuel</creatorcontrib><creatorcontrib>Aguayo de Hoyos, Eduardo</creatorcontrib><creatorcontrib>Ramos-Cuadra, José Ángel</creatorcontrib><creatorcontrib>Dı́az-Castellanos, Miguel Ángel</creatorcontrib><creatorcontrib>Issa-Khozouz, Ziad</creatorcontrib><creatorcontrib>Reina-Toral, Antonio</creatorcontrib><creatorcontrib>López-Martı́nez, Asunción</creatorcontrib><creatorcontrib>Calatrava-López, Jesús</creatorcontrib><creatorcontrib>Laynez-Bretones, Francisco</creatorcontrib><creatorcontrib>Castillo-Parra, Juan Carlos</creatorcontrib><creatorcontrib>De La Torre-Prados, Marı́a Victoria</creatorcontrib><creatorcontrib>for the ARIAM Group</creatorcontrib><creatorcontrib>ARIAM Group</creatorcontrib><title>Influence of age on clinical course, management and mortality of acute myocardial infarction in the Spanish population</title><title>International journal of cardiology</title><addtitle>Int J Cardiol</addtitle><description>Background: To assess age-related differences in cardiovascular risk factors, clinical course and management of patients with acute myocardial infarction (AMI) in intensive care (ICU) or coronary care units (CCU).
Methods: A retrospective cohort study was conducted of all AMI patients listed in the ARIAM register (Analysis of Delay in AMI), a multi-centre register in which 119 Spanish hospitals participated. The study period was from January 1995 to January 2001. A univariate analysis was carried out to evaluate differences between different age groups. Multivariate analysis was used to assess whether age difference was an independent predisposing factor for mortality and for differences in patient management.
Results: 17,761 patients were admitted to the ICUs/CCUs with a diagnosis of AMI. The distribution by ages was: <55 years, 3954 patients (22.3%); 55–64 years, 3593 (22.2%); 65–74 years, 5924 (33.4%); 75–84 years, 3686 (20.8%); and >84 years, 604 (3.4%) (
P<0.0001); 24.6% of the patients were female, and the relative proportion of females increased with age. There were clear differences in risk factors between the different age groups, with a predominance of tobacco, cholesterol and family history of heart disease in the younger patients. The incidence of complications, including haemorrhagic complications, increased significantly with age. The older age groups had a lower rate of thrombolysis and less use of revascularisation techniques. The mortality of the above groups was 2.6, 5.4, 10.7, 17.7 and 25.8%, respectively. Age difference was an independent predictive variable for mortality and the administration of thrombolysis.
Conclusions: The distinct age groups differed in cardiovascular risk factors, management and mortality. Age is a significant independent predictive variable for mortality and for the administration of thrombolysis.</description><subject>Acute myocardial infarction</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Age</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Child</subject><subject>Cohort Studies</subject><subject>Coronary heart disease</subject><subject>Elderly</subject><subject>Female</subject><subject>Heart</subject><subject>Humans</subject><subject>Incidence</subject><subject>Length of Stay</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Myocardial Infarction - complications</subject><subject>Myocardial Infarction - mortality</subject><subject>Myocardial Infarction - therapy</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Spain</subject><subject>Statistics as Topic</subject><subject>Thrombolysis</subject><subject>Thrombolytic Therapy - statistics & numerical data</subject><issn>0167-5273</issn><issn>1874-1754</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><recordid>eNqFkU1rFTEUhoMo9tr6E5RsFAWnZiZfN6sipdVCwUXrOpybObGRmcyYZAr33zf3A7t0k3dxnvckPCHkXcvOW9aqr3f10I3sNP_Eus-MtWvdsBdkVVM0rZbiJVn9Q07Im5z_MMaEMevX5KTtOraWRq3I4030w4LRIZ08hd81InVDiMHBQN20pIxf6AixjkaMhULs6TilAkMo233HLQXpuJ0cpD7UUogekiuhLgqRlgekdzPEkB_oPM3LALvJGXnlYcj49pin5Nf11f3lj-b25_eby2-3jROCl8YrhVxp02khGAdlhGcAnVYb1NCb3nmhes25AVAC0GxAOiE5uFYL3LSOn5KPh71zmv4umIsdQ3Y4DBBxWrLVHZNKSllBeQBdmnJO6O2cwghpa1tmd8LtXrjd2bSss3vhltXe--MFy2bE_rl1NFyBD0cAclXqE0QX8jPH18Ywwyt3ceCw6ngMmGx2YfcvfUjoiu2n8J-nPAEml56-</recordid><startdate>20021001</startdate><enddate>20021001</enddate><creator>Ruiz-Bailén, Manuel</creator><creator>Aguayo de Hoyos, Eduardo</creator><creator>Ramos-Cuadra, José Ángel</creator><creator>Dı́az-Castellanos, Miguel Ángel</creator><creator>Issa-Khozouz, Ziad</creator><creator>Reina-Toral, Antonio</creator><creator>López-Martı́nez, Asunción</creator><creator>Calatrava-López, Jesús</creator><creator>Laynez-Bretones, Francisco</creator><creator>Castillo-Parra, Juan Carlos</creator><creator>De La Torre-Prados, Marı́a Victoria</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20021001</creationdate><title>Influence of age on clinical course, management and mortality of acute myocardial infarction in the Spanish population</title><author>Ruiz-Bailén, Manuel ; Aguayo de Hoyos, Eduardo ; Ramos-Cuadra, José Ángel ; Dı́az-Castellanos, Miguel Ángel ; Issa-Khozouz, Ziad ; Reina-Toral, Antonio ; López-Martı́nez, Asunción ; Calatrava-López, Jesús ; Laynez-Bretones, Francisco ; Castillo-Parra, Juan Carlos ; De La Torre-Prados, Marı́a Victoria</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c443t-f66e3679274403a694f0aa276be7ad9dcf46d7339aa64ae9ba5c453ac174eb1c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Acute myocardial infarction</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Age</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Child</topic><topic>Cohort Studies</topic><topic>Coronary heart disease</topic><topic>Elderly</topic><topic>Female</topic><topic>Heart</topic><topic>Humans</topic><topic>Incidence</topic><topic>Length of Stay</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Myocardial Infarction - complications</topic><topic>Myocardial Infarction - mortality</topic><topic>Myocardial Infarction - therapy</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Spain</topic><topic>Statistics as Topic</topic><topic>Thrombolysis</topic><topic>Thrombolytic Therapy - statistics & numerical data</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ruiz-Bailén, Manuel</creatorcontrib><creatorcontrib>Aguayo de Hoyos, Eduardo</creatorcontrib><creatorcontrib>Ramos-Cuadra, José Ángel</creatorcontrib><creatorcontrib>Dı́az-Castellanos, Miguel Ángel</creatorcontrib><creatorcontrib>Issa-Khozouz, Ziad</creatorcontrib><creatorcontrib>Reina-Toral, Antonio</creatorcontrib><creatorcontrib>López-Martı́nez, Asunción</creatorcontrib><creatorcontrib>Calatrava-López, Jesús</creatorcontrib><creatorcontrib>Laynez-Bretones, Francisco</creatorcontrib><creatorcontrib>Castillo-Parra, Juan Carlos</creatorcontrib><creatorcontrib>De La Torre-Prados, Marı́a Victoria</creatorcontrib><creatorcontrib>for the ARIAM Group</creatorcontrib><creatorcontrib>ARIAM Group</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ruiz-Bailén, Manuel</au><au>Aguayo de Hoyos, Eduardo</au><au>Ramos-Cuadra, José Ángel</au><au>Dı́az-Castellanos, Miguel Ángel</au><au>Issa-Khozouz, Ziad</au><au>Reina-Toral, Antonio</au><au>López-Martı́nez, Asunción</au><au>Calatrava-López, Jesús</au><au>Laynez-Bretones, Francisco</au><au>Castillo-Parra, Juan Carlos</au><au>De La Torre-Prados, Marı́a Victoria</au><aucorp>for the ARIAM Group</aucorp><aucorp>ARIAM Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of age on clinical course, management and mortality of acute myocardial infarction in the Spanish population</atitle><jtitle>International journal of cardiology</jtitle><addtitle>Int J Cardiol</addtitle><date>2002-10-01</date><risdate>2002</risdate><volume>85</volume><issue>2</issue><spage>285</spage><epage>296</epage><pages>285-296</pages><issn>0167-5273</issn><eissn>1874-1754</eissn><coden>IJCDD5</coden><abstract>Background: To assess age-related differences in cardiovascular risk factors, clinical course and management of patients with acute myocardial infarction (AMI) in intensive care (ICU) or coronary care units (CCU).
Methods: A retrospective cohort study was conducted of all AMI patients listed in the ARIAM register (Analysis of Delay in AMI), a multi-centre register in which 119 Spanish hospitals participated. The study period was from January 1995 to January 2001. A univariate analysis was carried out to evaluate differences between different age groups. Multivariate analysis was used to assess whether age difference was an independent predisposing factor for mortality and for differences in patient management.
Results: 17,761 patients were admitted to the ICUs/CCUs with a diagnosis of AMI. The distribution by ages was: <55 years, 3954 patients (22.3%); 55–64 years, 3593 (22.2%); 65–74 years, 5924 (33.4%); 75–84 years, 3686 (20.8%); and >84 years, 604 (3.4%) (
P<0.0001); 24.6% of the patients were female, and the relative proportion of females increased with age. There were clear differences in risk factors between the different age groups, with a predominance of tobacco, cholesterol and family history of heart disease in the younger patients. The incidence of complications, including haemorrhagic complications, increased significantly with age. The older age groups had a lower rate of thrombolysis and less use of revascularisation techniques. The mortality of the above groups was 2.6, 5.4, 10.7, 17.7 and 25.8%, respectively. Age difference was an independent predictive variable for mortality and the administration of thrombolysis.
Conclusions: The distinct age groups differed in cardiovascular risk factors, management and mortality. Age is a significant independent predictive variable for mortality and for the administration of thrombolysis.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>12208596</pmid><doi>10.1016/S0167-5273(02)00187-0</doi><tpages>12</tpages></addata></record> |
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| subjects | Acute myocardial infarction Adolescent Adult Age Age Factors Aged Aged, 80 and over Biological and medical sciences Cardiology. Vascular system Child Cohort Studies Coronary heart disease Elderly Female Heart Humans Incidence Length of Stay Male Medical sciences Middle Aged Mortality Myocardial Infarction - complications Myocardial Infarction - mortality Myocardial Infarction - therapy Prognosis Retrospective Studies Risk Factors Spain Statistics as Topic Thrombolysis Thrombolytic Therapy - statistics & numerical data |
| title | Influence of age on clinical course, management and mortality of acute myocardial infarction in the Spanish population |
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