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Scaling of Atrioventricular Transmission in Mammalian Species: An Evolutionary Riddle
Scaling of AV Transmission.“Scaling deals with the structural and functional consequences of changes in size or scale among otherwise similar organisms.” It plays a key role in all studies on comparative mammalian physiology and morphology. Heart weight is proportionally related to body weight and c...
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| Published in: | Journal of cardiovascular electrophysiology 2002-08, Vol.13 (8), p.826-830 |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
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| container_end_page | 830 |
| container_issue | 8 |
| container_start_page | 826 |
| container_title | Journal of cardiovascular electrophysiology |
| container_volume | 13 |
| creator | MEIJLER, FRITS L. STRACKEE, JAN STOKHOF, ARNOLD A. WASSENAAR, CLAES |
| description | Scaling of AV Transmission.“Scaling deals with the structural and functional consequences of changes in size or scale among otherwise similar organisms.” It plays a key role in all studies on comparative mammalian physiology and morphology. Heart weight is proportionally related to body weight and can be described by a straightforward, so‐called allometric equation. We studied scaling of AV transmission times (PR intervals on the ECG) in 375 mammals of different dimensions and species. Scaling of AV transmission times versus heart length (third root of weight) is statistically best described by a S‐shaped curve. This implies that AV transmission time in mammals is not linearly related to heart length and does not depend solely on the length of the AV transmission system. The AV node fine‐tunes AV transmission times at rest and during exercise in individuals; it protects the ventricles against high‐rate atrial arrhythmias such as atrial fibrillation; and it regulates basal AV transmission times in mammalian species of varying sizes. We call the “how” and “why” of the scaling of AV transmission time in mammals an evolutionary riddle that deserves further study. |
| doi_str_mv | 10.1046/j.1540-8167.2002.00826.x |
| format | article |
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We call the “how” and “why” of the scaling of AV transmission time in mammals an evolutionary riddle that deserves further study.</description><identifier>ISSN: 1045-3873</identifier><identifier>EISSN: 1540-8167</identifier><identifier>DOI: 10.1046/j.1540-8167.2002.00826.x</identifier><identifier>PMID: 12212707</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Inc</publisher><subject>Age Factors ; Animals ; Animals, Newborn - physiology ; Atrioventricular Node - physiology ; Biomedical Engineering ; Body Composition - physiology ; Body Constitution - physiology ; Body Weight - physiology ; comparative atrioventricular transmission ; Electrocardiography ; evolution ; Heart - anatomy & histology ; mammalian heart ; Mammals - anatomy & histology ; Models, Animal ; Models, Cardiovascular ; Organ Size - physiology ; Physiology, Comparative ; scaling ; Signal Transduction - physiology</subject><ispartof>Journal of cardiovascular electrophysiology, 2002-08, Vol.13 (8), p.826-830</ispartof><rights>Futura Publishing Company, Inc. 2002</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4526-53ba87808a4e469d28609a4dfa9891912ac45916aceaab9fff4f8432cd0236ac3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12212707$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MEIJLER, FRITS L.</creatorcontrib><creatorcontrib>STRACKEE, JAN</creatorcontrib><creatorcontrib>STOKHOF, ARNOLD A.</creatorcontrib><creatorcontrib>WASSENAAR, CLAES</creatorcontrib><title>Scaling of Atrioventricular Transmission in Mammalian Species: An Evolutionary Riddle</title><title>Journal of cardiovascular electrophysiology</title><addtitle>J Cardiovasc Electrophysiol</addtitle><description>Scaling of AV Transmission.“Scaling deals with the structural and functional consequences of changes in size or scale among otherwise similar organisms.” It plays a key role in all studies on comparative mammalian physiology and morphology. Heart weight is proportionally related to body weight and can be described by a straightforward, so‐called allometric equation. We studied scaling of AV transmission times (PR intervals on the ECG) in 375 mammals of different dimensions and species. Scaling of AV transmission times versus heart length (third root of weight) is statistically best described by a S‐shaped curve. This implies that AV transmission time in mammals is not linearly related to heart length and does not depend solely on the length of the AV transmission system. The AV node fine‐tunes AV transmission times at rest and during exercise in individuals; it protects the ventricles against high‐rate atrial arrhythmias such as atrial fibrillation; and it regulates basal AV transmission times in mammalian species of varying sizes. We call the “how” and “why” of the scaling of AV transmission time in mammals an evolutionary riddle that deserves further study.</description><subject>Age Factors</subject><subject>Animals</subject><subject>Animals, Newborn - physiology</subject><subject>Atrioventricular Node - physiology</subject><subject>Biomedical Engineering</subject><subject>Body Composition - physiology</subject><subject>Body Constitution - physiology</subject><subject>Body Weight - physiology</subject><subject>comparative atrioventricular transmission</subject><subject>Electrocardiography</subject><subject>evolution</subject><subject>Heart - anatomy & histology</subject><subject>mammalian heart</subject><subject>Mammals - anatomy & histology</subject><subject>Models, Animal</subject><subject>Models, Cardiovascular</subject><subject>Organ Size - physiology</subject><subject>Physiology, Comparative</subject><subject>scaling</subject><subject>Signal Transduction - physiology</subject><issn>1045-3873</issn><issn>1540-8167</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><recordid>eNqNkE1PGzEQhq2Kqnz1L1Q-9bbL-GNtb8UligK0oq0gII7WZNdbOexHsLMQ_n2dJqJXTjOyn3dm9BBCGeQMpDpb5qyQkBmmdM4BeA5guMo3H8jR28dB6kEWmTBaHJLjGJcATCgoPpFDxjnjGvQRuZ9X2Pr-Dx0aOlkHPzy7PpVqbDHQu4B97HyMfuip7-lP7LpEY0_nK1d5F7_RSU9nz0M7rhOC4ZXe-rpu3Sn52GAb3ed9PSH3F7O76VV2_fvy-3RynVWy4CorxAKNNmBQOqnKmhsFJcq6wdKUrGQcE1cyhZVDXJRN08jGSMGrGrhIr-KEfN3NXYXhaXRxbdO1lWtb7N0wRqs5FLoQOoFmB1ZhiDG4xq6C79LBloHdKrVLuzVnt-bsVqn9p9RuUvTLfse46Fz9P7h3mIDzHfDiW_f67sH2x3SWmhTPdnEf127zFsfwaJUWurAPvy6t1vObG_NwYY34C56YlCw</recordid><startdate>200208</startdate><enddate>200208</enddate><creator>MEIJLER, FRITS L.</creator><creator>STRACKEE, JAN</creator><creator>STOKHOF, ARNOLD A.</creator><creator>WASSENAAR, CLAES</creator><general>Blackwell Science Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200208</creationdate><title>Scaling of Atrioventricular Transmission in Mammalian Species: An Evolutionary Riddle</title><author>MEIJLER, FRITS L. ; STRACKEE, JAN ; STOKHOF, ARNOLD A. ; WASSENAAR, CLAES</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4526-53ba87808a4e469d28609a4dfa9891912ac45916aceaab9fff4f8432cd0236ac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Age Factors</topic><topic>Animals</topic><topic>Animals, Newborn - physiology</topic><topic>Atrioventricular Node - physiology</topic><topic>Biomedical Engineering</topic><topic>Body Composition - physiology</topic><topic>Body Constitution - physiology</topic><topic>Body Weight - physiology</topic><topic>comparative atrioventricular transmission</topic><topic>Electrocardiography</topic><topic>evolution</topic><topic>Heart - anatomy & histology</topic><topic>mammalian heart</topic><topic>Mammals - anatomy & histology</topic><topic>Models, Animal</topic><topic>Models, Cardiovascular</topic><topic>Organ Size - physiology</topic><topic>Physiology, Comparative</topic><topic>scaling</topic><topic>Signal Transduction - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MEIJLER, FRITS L.</creatorcontrib><creatorcontrib>STRACKEE, JAN</creatorcontrib><creatorcontrib>STOKHOF, ARNOLD A.</creatorcontrib><creatorcontrib>WASSENAAR, CLAES</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cardiovascular electrophysiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MEIJLER, FRITS L.</au><au>STRACKEE, JAN</au><au>STOKHOF, ARNOLD A.</au><au>WASSENAAR, CLAES</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Scaling of Atrioventricular Transmission in Mammalian Species: An Evolutionary Riddle</atitle><jtitle>Journal of cardiovascular electrophysiology</jtitle><addtitle>J Cardiovasc Electrophysiol</addtitle><date>2002-08</date><risdate>2002</risdate><volume>13</volume><issue>8</issue><spage>826</spage><epage>830</epage><pages>826-830</pages><issn>1045-3873</issn><eissn>1540-8167</eissn><abstract>Scaling of AV Transmission.“Scaling deals with the structural and functional consequences of changes in size or scale among otherwise similar organisms.” It plays a key role in all studies on comparative mammalian physiology and morphology. 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| fulltext | fulltext |
| identifier | ISSN: 1045-3873 |
| ispartof | Journal of cardiovascular electrophysiology, 2002-08, Vol.13 (8), p.826-830 |
| issn | 1045-3873 1540-8167 |
| language | eng |
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| source | Wiley |
| subjects | Age Factors Animals Animals, Newborn - physiology Atrioventricular Node - physiology Biomedical Engineering Body Composition - physiology Body Constitution - physiology Body Weight - physiology comparative atrioventricular transmission Electrocardiography evolution Heart - anatomy & histology mammalian heart Mammals - anatomy & histology Models, Animal Models, Cardiovascular Organ Size - physiology Physiology, Comparative scaling Signal Transduction - physiology |
| title | Scaling of Atrioventricular Transmission in Mammalian Species: An Evolutionary Riddle |
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