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Immunoglobulin G antibody avidity assay for serodiagnosis of hepatitis C virus infection
It has been reported that the avidity of specific IgG antibody is lower in primary viral infection than in chronic viral infection. However, few studies have been reported on the IgG avidity in hepatitis C virus (HCV) infection. In the present study, 36 patients with antibody to HCV (anti‐HCV) were...
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| Published in: | Journal of medical virology 2002-10, Vol.68 (2), p.229-233 |
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| container_end_page | 233 |
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| container_title | Journal of medical virology |
| container_volume | 68 |
| creator | Kanno, Atsushi Kazuyama, Yukumasa |
| description | It has been reported that the avidity of specific IgG antibody is lower in primary viral infection than in chronic viral infection. However, few studies have been reported on the IgG avidity in hepatitis C virus (HCV) infection. In the present study, 36 patients with antibody to HCV (anti‐HCV) were examined for IgG avidity by an enzyme immunoassay with or without urea elution. The avidity index was significantly low in patients with primary HCV infection (7.7 ± 6.8%, mean ± SD), compared with patients with chronic HCV infection (77.0 ± 21.8%) and individuals with past HCV infection (44.5 ± 12.6%). Temporal changes of IgG avidity were examined in six patients with primary HCV infection. The avidity index was low in the acute phase of the infection and then increased with time. These results suggest that the avidity assay for IgG anti‐HCV is a useful method for distinguishing primary HCV infection from chronic or past HCV infection. J. Med. Virol. 68:229–233, 2002. © 2002 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/jmv.10186 |
| format | article |
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However, few studies have been reported on the IgG avidity in hepatitis C virus (HCV) infection. In the present study, 36 patients with antibody to HCV (anti‐HCV) were examined for IgG avidity by an enzyme immunoassay with or without urea elution. The avidity index was significantly low in patients with primary HCV infection (7.7 ± 6.8%, mean ± SD), compared with patients with chronic HCV infection (77.0 ± 21.8%) and individuals with past HCV infection (44.5 ± 12.6%). Temporal changes of IgG avidity were examined in six patients with primary HCV infection. The avidity index was low in the acute phase of the infection and then increased with time. These results suggest that the avidity assay for IgG anti‐HCV is a useful method for distinguishing primary HCV infection from chronic or past HCV infection. J. Med. Virol. 68:229–233, 2002. © 2002 Wiley‐Liss, Inc.</description><identifier>ISSN: 0146-6615</identifier><identifier>EISSN: 1096-9071</identifier><identifier>DOI: 10.1002/jmv.10186</identifier><identifier>PMID: 12210412</identifier><identifier>CODEN: JMVIDB</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Acute Disease ; Adult ; anti-HCV ; Antibody Affinity ; avidity ; Bacterial diseases ; Bacteriology ; Biological and medical sciences ; Experimental bacterial diseases and models ; Female ; Fundamental and applied biological sciences. Psychology ; Hepacivirus - immunology ; Hepacivirus - isolation & purification ; Hepatitis C - diagnosis ; Hepatitis C - immunology ; Hepatitis C - virology ; Hepatitis C Antibodies - blood ; Hepatitis C, Chronic - diagnosis ; Hepatitis C, Chronic - immunology ; Hepatitis C, Chronic - virology ; Humans ; IgG ; Immunoglobulin G - blood ; Infectious diseases ; Male ; Medical sciences ; Microbiology ; Middle Aged ; Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains ; RNA, Viral - blood ; Serologic Tests ; Time Factors</subject><ispartof>Journal of medical virology, 2002-10, Vol.68 (2), p.229-233</ispartof><rights>Copyright © 2002 Wiley‐Liss, Inc.</rights><rights>2003 INIST-CNRS</rights><rights>Copyright 2002 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4866-5c0f5fe5c9d325bbf99eb791952aa11b625da310bee6b215f18d97d8cce6c1983</citedby><cites>FETCH-LOGICAL-c4866-5c0f5fe5c9d325bbf99eb791952aa11b625da310bee6b215f18d97d8cce6c1983</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13867953$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12210412$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kanno, Atsushi</creatorcontrib><creatorcontrib>Kazuyama, Yukumasa</creatorcontrib><title>Immunoglobulin G antibody avidity assay for serodiagnosis of hepatitis C virus infection</title><title>Journal of medical virology</title><addtitle>J. Med. Virol</addtitle><description>It has been reported that the avidity of specific IgG antibody is lower in primary viral infection than in chronic viral infection. However, few studies have been reported on the IgG avidity in hepatitis C virus (HCV) infection. In the present study, 36 patients with antibody to HCV (anti‐HCV) were examined for IgG avidity by an enzyme immunoassay with or without urea elution. The avidity index was significantly low in patients with primary HCV infection (7.7 ± 6.8%, mean ± SD), compared with patients with chronic HCV infection (77.0 ± 21.8%) and individuals with past HCV infection (44.5 ± 12.6%). Temporal changes of IgG avidity were examined in six patients with primary HCV infection. The avidity index was low in the acute phase of the infection and then increased with time. These results suggest that the avidity assay for IgG anti‐HCV is a useful method for distinguishing primary HCV infection from chronic or past HCV infection. J. Med. Virol. 68:229–233, 2002. © 2002 Wiley‐Liss, Inc.</description><subject>Acute Disease</subject><subject>Adult</subject><subject>anti-HCV</subject><subject>Antibody Affinity</subject><subject>avidity</subject><subject>Bacterial diseases</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Experimental bacterial diseases and models</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hepacivirus - immunology</subject><subject>Hepacivirus - isolation & purification</subject><subject>Hepatitis C - diagnosis</subject><subject>Hepatitis C - immunology</subject><subject>Hepatitis C - virology</subject><subject>Hepatitis C Antibodies - blood</subject><subject>Hepatitis C, Chronic - diagnosis</subject><subject>Hepatitis C, Chronic - immunology</subject><subject>Hepatitis C, Chronic - virology</subject><subject>Humans</subject><subject>IgG</subject><subject>Immunoglobulin G - blood</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains</subject><subject>RNA, Viral - blood</subject><subject>Serologic Tests</subject><subject>Time Factors</subject><issn>0146-6615</issn><issn>1096-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><recordid>eNqF0E1P2zAYB3ALbYKOceALTL5s0g4BP3btxEdUjY6KsQvberNsx2aGJC520q3ffoEWOKGdHlv6PS_6I3QM5AQIoae37Xp8QCX20ASIFIUkJbxBEwJTUQgB_AC9y_mWEFJJSvfRAVAKZAp0gpYXbTt08aaJZmhCh-dYd30wsd5gvQ516Meas95gHxPOLsU66Jsu5pBx9Pi3W-k-9ONnhtchDRmHzjvbh9i9R2-9brI72tVD9OP8y_Xsa3H5fX4xO7ss7LQSouCWeO4dt7JmlBvjpXSmlCA51RrACMprzYAY54ShwD1UtSzrylonLMiKHaJP27mrFO8Hl3vVhmxd0-jOxSGrkhIuuWT_hVCNBzEqR_h5C22KOSfn1SqFVqeNAqIe8lZj3uox79F-2A0dTOvqF7kLeAQfd0BnqxufdGdDfnGsEqXkD9edbt2f0LjN6xvV4tvPp9XFtiPk3v197tDpTomSlVz9upqr2XJ5zRfnC8XYP9wFpvc</recordid><startdate>200210</startdate><enddate>200210</enddate><creator>Kanno, Atsushi</creator><creator>Kazuyama, Yukumasa</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200210</creationdate><title>Immunoglobulin G antibody avidity assay for serodiagnosis of hepatitis C virus infection</title><author>Kanno, Atsushi ; Kazuyama, Yukumasa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4866-5c0f5fe5c9d325bbf99eb791952aa11b625da310bee6b215f18d97d8cce6c1983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Acute Disease</topic><topic>Adult</topic><topic>anti-HCV</topic><topic>Antibody Affinity</topic><topic>avidity</topic><topic>Bacterial diseases</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Experimental bacterial diseases and models</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hepacivirus - immunology</topic><topic>Hepacivirus - isolation & purification</topic><topic>Hepatitis C - diagnosis</topic><topic>Hepatitis C - immunology</topic><topic>Hepatitis C - virology</topic><topic>Hepatitis C Antibodies - blood</topic><topic>Hepatitis C, Chronic - diagnosis</topic><topic>Hepatitis C, Chronic - immunology</topic><topic>Hepatitis C, Chronic - virology</topic><topic>Humans</topic><topic>IgG</topic><topic>Immunoglobulin G - blood</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Middle Aged</topic><topic>Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains</topic><topic>RNA, Viral - blood</topic><topic>Serologic Tests</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kanno, Atsushi</creatorcontrib><creatorcontrib>Kazuyama, Yukumasa</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of medical virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kanno, Atsushi</au><au>Kazuyama, Yukumasa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunoglobulin G antibody avidity assay for serodiagnosis of hepatitis C virus infection</atitle><jtitle>Journal of medical virology</jtitle><addtitle>J. Med. Virol</addtitle><date>2002-10</date><risdate>2002</risdate><volume>68</volume><issue>2</issue><spage>229</spage><epage>233</epage><pages>229-233</pages><issn>0146-6615</issn><eissn>1096-9071</eissn><coden>JMVIDB</coden><abstract>It has been reported that the avidity of specific IgG antibody is lower in primary viral infection than in chronic viral infection. However, few studies have been reported on the IgG avidity in hepatitis C virus (HCV) infection. In the present study, 36 patients with antibody to HCV (anti‐HCV) were examined for IgG avidity by an enzyme immunoassay with or without urea elution. The avidity index was significantly low in patients with primary HCV infection (7.7 ± 6.8%, mean ± SD), compared with patients with chronic HCV infection (77.0 ± 21.8%) and individuals with past HCV infection (44.5 ± 12.6%). Temporal changes of IgG avidity were examined in six patients with primary HCV infection. The avidity index was low in the acute phase of the infection and then increased with time. These results suggest that the avidity assay for IgG anti‐HCV is a useful method for distinguishing primary HCV infection from chronic or past HCV infection. J. Med. Virol. 68:229–233, 2002. © 2002 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>12210412</pmid><doi>10.1002/jmv.10186</doi><tpages>5</tpages></addata></record> |
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| subjects | Acute Disease Adult anti-HCV Antibody Affinity avidity Bacterial diseases Bacteriology Biological and medical sciences Experimental bacterial diseases and models Female Fundamental and applied biological sciences. Psychology Hepacivirus - immunology Hepacivirus - isolation & purification Hepatitis C - diagnosis Hepatitis C - immunology Hepatitis C - virology Hepatitis C Antibodies - blood Hepatitis C, Chronic - diagnosis Hepatitis C, Chronic - immunology Hepatitis C, Chronic - virology Humans IgG Immunoglobulin G - blood Infectious diseases Male Medical sciences Microbiology Middle Aged Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains RNA, Viral - blood Serologic Tests Time Factors |
| title | Immunoglobulin G antibody avidity assay for serodiagnosis of hepatitis C virus infection |
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