Synthesis and Antimicrobial Activity of Some 2-[p-Substituted-phenyl]benzoxazol-5-yl-arylcarboxyamides

• Published in: Archiv der Pharmazie (Weinheim) 2002-08, Vol.335 (6), p.283-288
• Main Authors: Temiz-Arpaci, Özlem, Aki-Şener, Esin, Yalçin, Ismail, Altanlar, Nurten
• Format: Article
• Language: English
• Subjects: Anti-Bacterial Agents; Anti-Infective Agents - chemical synthesis; Anti-Infective Agents - chemistry; Anti-Infective Agents - pharmacology; Antibacterial agents; Antibacterial and antifungal activity; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antifungal agents; Bacteria - drug effects; Benzoxazole-5-yl-arylcarboxyamides; Benzoxazoles - chemical synthesis; Benzoxazoles - pharmacology; Biological and medical sciences; Fungi - drug effects; Magnetic Resonance Spectroscopy; Medical sciences; Microbial Sensitivity Tests; Pharmacology. Drug treatments; Spectrophotometry, Infrared; Structure-Activity Relationship
• ISSN: 0365-6233; 1521-4184
• DOI: 10.1002/1521-4184(200208)335:6<283::AID-ARDP283>3.0.CO;2-M

New 2‐[p‐substituted‐phenyl ]benzoxazol‐5‐yl‐arylcarboxyamides derivatives have been synthesized by reacting 5‐amino‐2‐[p‐substituted‐phenyl ]benzoxazoles with substituted‐arylcarboxylic acid chlorides. The structures of the synthesized compounds were confirmed by IR and 1H NMR spectral data. Antimicrobial activities of the compounds were investigated using the two‐fold serial dilution technique against different Gram‐positive and Gram‐negative bacteria and the yeast C. albicans in comparison with standard drugs. Microbiological results indicated that the synthesized compounds possess a broad spectrum of activity, having an MIC value of 25‐200 μg/mL at molar concentration values of 3.45 ? 10‐5 and 5.74 ? 10‐4 against the tested microorganisms.