Salivary duct carcinoma: cytokeratin 14 as a marker of in-situ intraductal growth

Aims:  The aim of this study was to determine the immunoprofile of salivary duct carcinoma and to differentiate intraductal growth from invasive growth. Methods and results:  We applied a panel of antibodies (cytokeratins 7, 8, 13, 14, 19, vimentin and α‐smooth muscle actin) in five cases of salivar...

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Published in:Histopathology 2002-09, Vol.41 (3), p.244-249
Main Authors: De Araújo, V C, Loducca, S V L, Sobral, A P V, Kowalski, L P, Soares, F, De Araújo, N S
Format: Article
Language:English
Subjects:
Adenocarcinoma - metabolism
Adenocarcinoma - pathology
Aged
Biological and medical sciences
Biomarkers, Tumor - metabolism
cytokeratins
Female
Humans
Immunohistochemistry
Keratins - metabolism
Male
Medical sciences
Middle Aged
Otorhinolaryngology. Stomatology
Parotid Neoplasms - metabolism
Parotid Neoplasms - pathology
salivary duct carcinoma
Tumors
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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Summary:Aims:  The aim of this study was to determine the immunoprofile of salivary duct carcinoma and to differentiate intraductal growth from invasive growth. Methods and results:  We applied a panel of antibodies (cytokeratins 7, 8, 13, 14, 19, vimentin and α‐smooth muscle actin) in five cases of salivary duct carcinoma. This panel is currently used for identification of different components of salivary gland tumours in our laboratory. All tumour cells were positive for cytokeratins 7 and 8. Few neoplastic structures expressed cytokeratin 14 in cells surrounding tumour islands. Conclusion:  The finding of cytokeratin 14 was important to confirm the in‐situ intraductal growth, which probably characterizes this low‐grade neoplasm.
ISSN:0309-0167
1365-2559
DOI:10.1046/j.1365-2559.2002.01454.x