Resistin expression and regulation in mouse pituitary

Resistin, a new adipocytokine, is expressed in human, rat and mouse adipose tissue. Its putative role as a mediator of insulin resistance is controversial. We hypothesized that resistin, in common with leptin, has multiple roles in non-adipose tissues. Using reverse transcription polymerase chain re...

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Bibliographic Details
Published in:FEBS letters 2002-08, Vol.526 (1), p.26-30
Main Authors: Morash, Barbara A, Willkinson, Diane, Ur, Ehud, Wilkinson, Michael
Format: Article
Language:English
Subjects:
Aging - physiology
Animals
Brain - growth & development
Brain - metabolism
Female
Gene Expression Regulation, Developmental - physiology
Hormones, Ectopic - genetics
Hypothalamus
Intercellular Signaling Peptides and Proteins
Mice
Mice, Inbred C57BL
Nerve Growth Factor
Ontogeny
Organ Specificity
Pituitary
Pituitary Gland - growth & development
Pituitary Gland - metabolism
Proteins
Resistin
Reverse Transcriptase Polymerase Chain Reaction
Reverse transcription polymerase chain reaction
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Summary:Resistin, a new adipocytokine, is expressed in human, rat and mouse adipose tissue. Its putative role as a mediator of insulin resistance is controversial. We hypothesized that resistin, in common with leptin, has multiple roles in non-adipose tissues. Using reverse transcription polymerase chain reaction (RT-PCR) we show that the resistin gene ( Retn) is expressed in mouse brain (hypothalamus and cortex) and pituitary gland. Immunohistochemistry revealed resistin protein in the arcuate nucleus and pituitary gland. Semi-quantitative RT-PCR analysis indicated that Retn mRNA is developmentally regulated in the pituitary. Expression was lowest at birth, increased abruptly between postnatal days 14 and 25 (four-fold; P
ISSN:0014-5793
1873-3468
DOI:10.1016/S0014-5793(02)03108-3