Effects of 5-HT-1A receptor agonists on CRF-induced behavior

Buspirone (2.0 or 4.0 mg/kg) and 8-hydroxy-2-(di-N-propylamino)-tetralin (8-OH-DPAT) (0.25 or 0.5 mg/kg) were used to examine the effects of serotonin 1A receptor agonists on the behavioral response of rats to centrally administered corticotropin-releasing factor (CRF). Behavioral observations were...

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Bibliographic Details
Published in:Psychopharmacologia 1991-01, Vol.104 (1), p.132-136
Main Authors: LAZOSKY, A. J, BRITTON, D. R
Format: Article
Language:English
Subjects:
8-Hydroxy-2-(di-n-propylamino)tetralin
Animals
Behavior, Animal - drug effects
Biological and medical sciences
Buspirone - pharmacology
Corticotropin-Releasing Hormone - administration & dosage
Corticotropin-Releasing Hormone - pharmacology
Eating - drug effects
Grooming - drug effects
Injections, Intraventricular
Male
Medical sciences
Motor Activity - drug effects
Neuropharmacology
Pharmacology. Drug treatments
Psycholeptics: tranquillizer, neuroleptic
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Rats
Rats, Inbred Strains
Receptors, Serotonin - drug effects
Tetrahydronaphthalenes - pharmacology
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Summary:Buspirone (2.0 or 4.0 mg/kg) and 8-hydroxy-2-(di-N-propylamino)-tetralin (8-OH-DPAT) (0.25 or 0.5 mg/kg) were used to examine the effects of serotonin 1A receptor agonists on the behavioral response of rats to centrally administered corticotropin-releasing factor (CRF). Behavioral observations were done with animals in their home cages. Parameters measured included locomotor activity, grooming and food consumption. CRF alone increased locomotor activity. 8-OH-DPAT also increased locomotion in both saline control and CRF-treated rats. Buspirone had no effect on basal locomotion or on CRF-induced hyperactivity. Both buspirone and 8-OH-DPAT antagonized CRF-induced grooming. Food consumption by fasted rats was suppressed by ICV CRF. 8-OH-DPAT suppressed eating by both ICV CRF and ICV saline-treated animals, while buspirone was without effect. These results demonstrate differences between the two putative 5-HT-1A agonists in their effects on CRF-induced behaviour but also demonstrate that both suppress CRF-induced grooming.
ISSN:0033-3158
1432-2072
DOI:10.1007/BF02244567