Plasma homocysteine levels and atherosclerosis in Japan: Epidemiological study by use of carotid ultrasonography

We examined whether hyperhomocysteinemia is an independent risk factor for increased carotid artery intimal-medial wall thickness (IMT) in a large, randomly selected community in Japan where the dietary habit is different and the incidence of coronary artery disease is lower compared with those of w...

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Bibliographic Details
Published in:Stroke (1970) 2002-09, Vol.33 (9), p.2177-2181
Main Authors: ADACHI, Hisashi, HIRAI, Yuji, FUJIURA, Yoshihisa, MATSUOKA, Hidehiro, SATOH, Akira, IMAIZUMI, Tsutomu
Format: Article
Language:English
Subjects:
Adult
Age Distribution
Aged
Aged, 80 and over
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Carotid Arteries - diagnostic imaging
Carotid Artery Diseases - blood
Carotid Artery Diseases - diagnostic imaging
Carotid Artery Diseases - epidemiology
Creatinine - blood
Female
Homocysteine - blood
Humans
Japan - epidemiology
Male
Medical sciences
Middle Aged
Predictive Value of Tests
Regression Analysis
Risk Factors
Sex Distribution
Tunica Intima - diagnostic imaging
Tunica Media - diagnostic imaging
Ultrasonography
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Summary:We examined whether hyperhomocysteinemia is an independent risk factor for increased carotid artery intimal-medial wall thickness (IMT) in a large, randomly selected community in Japan where the dietary habit is different and the incidence of coronary artery disease is lower compared with those of western countries. In 1111 cases (452 men, 659 women) aged 63+/-10 years old (range, 40 to 94 years) recruited from a population-based survey performed in 1999, we measured fasting plasma total homocysteine levels and performed bilateral carotid B-mode ultrasound. The participants underwent measurements of other blood chemistries (total cholesterol, HDL cholesterol, glycosylated hemoglobin A(1c), and creatinine). For the total population, the mean total homocysteine level was 10.9 micro mol/L. Total homocysteine levels were higher in men than in women and increased with aging. With multiple linear regression analysis after adjustments for age and sex, the most powerful determinant of total homocysteine levels was serum creatinine (P
ISSN:0039-2499
1524-4628
DOI:10.1161/01.STR.0000026861.18199.89