Antisense RNA

RNA-RNA interactions have been shown to play key structural and enzymatic roles in several aspects of cellular processes, including transcription, translation, RNA processing, and regulation of DNA replication. Recently, it was found that a small RNA can bind to a complementary region of a target RN...

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Bibliographic Details
Published in:Annual review of biochemistry 1991-01, Vol.60 (1), p.631-652
Main Authors: Eguchi, Y, Itoh, T, Tomizawa, J
Format: Article
Language:English
Subjects:
Analytical, structural and metabolic biochemistry
Base Sequence
Biological and medical sciences
DNA Replication
Fundamental and applied biological sciences. Psychology
Molecular Sequence Data
Nucleic Acid Conformation
Nucleic acids
RNA - chemistry
RNA - metabolism
RNA, Antisense - physiology
Rna, ribonucleoproteins
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Summary:RNA-RNA interactions have been shown to play key structural and enzymatic roles in several aspects of cellular processes, including transcription, translation, RNA processing, and regulation of DNA replication. Recently, it was found that a small RNA can bind to a complementary region of a target RNA and affect its function. An RNA that interferes with the activity of another RNA in this manner is defined as an antisense RNA. In this paper, we review regulation by antisense RNAs and examine the more general question of the mechanism of RNA-RNA interactions.
ISSN:0066-4154
1545-4509
DOI:10.1146/annurev.bi.60.070191.003215