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In vitro evaluation of phosphonylated low-density polyethylene for vascular applications

The use of catheters for vascular applications is often complicated by the development of friction between the catheter material and the vessel wall, which leads to endothelial cell removal and intimal lesions. Phosphonylation, a chemical surface treatment, has been proposed as a means of increasing...

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Bibliographic Details
Published in:Journal of biomedical materials research 2002-12, Vol.62 (4), p.514-524
Main Authors: Caldwell, Rebecca A., Woodell, Jennifer E., Ho, Sunita Pullela, Shalaby, Shalaby W., Boland, Thomas, Langan, Eugene M., Laberge, Martine
Format: Article
Language:English
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Summary:The use of catheters for vascular applications is often complicated by the development of friction between the catheter material and the vessel wall, which leads to endothelial cell removal and intimal lesions. Phosphonylation, a chemical surface treatment, has been proposed as a means of increasing the hydrophilicity of low‐density polyethylene (LDPE), a commonly used catheter material, in efforts to impart lubricity to the material and reduce vascular tissue damage. In an in vitro tribological study, phosphonylated LDPE produced a lower coefficient of friction and allowed greater retention of endothelial cells on vessels as compared to untreated LDPE when the materials were reciprocated against normal porcine aorta. Chemical characterizations of the LDPE before and after friction testing involving Fourier transform infrared and energy‐dispersive X‐ray (EDX) confirmed the phosphorus content on phosphonylated LDPE. Election spectroscopy for chemical analysis (ESCA) and atomic force micrscope (AFM) analyses verified that proteins initially adsorb to both the phosphonylated and untreated LDPE surfaces and that the proteins interfere with water to lubricate the surfaces. However, with repeated friction, proteins are removed from the surface and hydrophilicity, as imparted by phosphonylation, becomes a principal factor in the lubrication process. © 2002 Wiley Periodicals, Inc. J Biomed Mater Res 62: 514–524, 2002
ISSN:0021-9304
1097-4636
DOI:10.1002/jbm.10249