Southern Association for Vascular Surgery William J. von Leibig Award. Inflammation and intimal hyperplasia associated with experimental pulmonary embolism

We tested the hypothesis that a venous thromboembolism to the pulmonary arterial system (pulmonary embolism [PE]) would cause an inflammatory response within the pulmonary arterial (PA) wall marked by elevated cytokines and chemokines and an influx of inflammatory cells. Experimental PE was induced...

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Bibliographic Details
Published in:Journal of vascular surgery 2002-09, Vol.36 (3), p.581-588
Main Authors: Eagleton, Matthew J, Henke, Peter K, Luke, Catherine E, Hawley, Angela E, Bedi, Asheesh, Knipp, Brian S, Wakefield, Thomas W, Greenfield, Lazar J
Format: Article
Language:English
Subjects:
Animals
Arteritis - etiology
Arteritis - pathology
Arteritis - physiopathology
Chemokines - analysis
Cytokines - analysis
Disease Models, Animal
Hyperplasia - etiology
Hyperplasia - pathology
Hyperplasia - physiopathology
Inflammation - etiology
Inflammation - pathology
Inflammation - physiopathology
Pulmonary Artery - pathology
Pulmonary Artery - physiopathology
Pulmonary Embolism - complications
Pulmonary Embolism - pathology
Pulmonary Embolism - physiopathology
Rats
Rats, Sprague-Dawley
Time Factors
Tunica Intima - pathology
Tunica Intima - physiopathology
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Summary:We tested the hypothesis that a venous thromboembolism to the pulmonary arterial system (pulmonary embolism [PE]) would cause an inflammatory response within the pulmonary arterial (PA) wall marked by elevated cytokines and chemokines and an influx of inflammatory cells. Experimental PE was induced in 70 rats and confirmed with angiography and O(2) saturation depression, and an additional 70 rats underwent sham operations. PA and lung tissue were removed at 3 hours and at 1, 2, 4, 6, 8, and 14 days (n = 10 per time point), were analyzed for proinflammatory cytokines and chemokines, and underwent histologic analysis. Data were analyzed with analysis of variance and the unpaired Student t test. Average gross PE resolution was 40% at 2 days, 90% at 4 days, and 100% at 6 days. Only monocyte chemoattractant protein-1 levels were greater in affected PAs compared with sham PAs at 3 hours, 1 day, and 2 days (137 +/- 13 pg/mg protein, 285 +/- 40 pg/mg protein, and 249 +/- 36 pg/mg protein versus 101 +/- 6 pg/mg protein, 150 +/- 36 pg/mg protein, and 92 +/- 3 pg/mg protein; P
ISSN:0741-5214