Elevated interleukin-2, interleukin-6 and interleukin-8 serum levels in neuroleptic-free schizophrenia: association with psychopathology

Cytokines have been one of the recent focal points of immunological research in schizophrenia. The present study was to assess the serum levels of some of interleukins in schizophrenia and their relationships with the psychopathological parameters. Seventy physically healthy Chinese patients, who me...

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Bibliographic Details
Published in:Schizophrenia research 2002-10, Vol.57 (2), p.247-258
Main Authors: Zhang, Xiang Yang, Zhou, Dong Feng, Zhang, Pei Yan, Wu, Gui Ying, Cao, Lian Yuan, Shen, Yu Cun
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Analysis of Variance
Biological and medical sciences
Case-Control Studies
China
Female
Humans
Immune
Interleukin
Interleukin-2 - blood
Interleukin-6 - blood
Interleukin-8 - blood
Male
Medical sciences
Middle Aged
Psychiatric Status Rating Scales
Psychology. Psychoanalysis. Psychiatry
Psychopathology
Psychopathology. Psychiatry
Psychoses
Schizophrenia
Schizophrenia - immunology
Schizophrenic Psychology
Statistics, Nonparametric
Symptom
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Summary:Cytokines have been one of the recent focal points of immunological research in schizophrenia. The present study was to assess the serum levels of some of interleukins in schizophrenia and their relationships with the psychopathological parameters. Seventy physically healthy Chinese patients, who met DSM-III-R criteria for schizophrenia and who were drug-free for at least 2 weeks, were compared with 30 age- and sex-matched Chinese normal controls. The psychopathology of schizophrenia was assessed by the Positive and Negative Syndrome Scale (PANSS). Serum levels of IL-6 and IL-8 were measured by sandwich enzyme-linked immunosorbent assay (ELISA), and serum IL-2 level was assayed by radioimmunometric assay (RIA). Serum levels of IL-2, IL-6 and IL-8 were significantly elevated in patients with a chronic form of schizophrenia (all p
ISSN:0920-9964
1573-2509
DOI:10.1016/S0920-9964(01)00296-1