Polyhydroxy alkaloids: chromatographic analysis

Polyhydroxy alkaloids are a burgeoning category of natural products that encompass several structural types and generally exhibit potent activity as inhibitors of glycosidases. As presently defined the group consists of monocyclic or bicyclic alkaloids of the pyrrolidine, piperidine, pyrrolizidine,...

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Bibliographic Details
Published in:Journal of Chromatography A 2002-08, Vol.967 (1), p.57-74
Main Authors: Molyneux, Russell J, Gardner, Dale R, James, Lynn F, Colegate, Steven M
Format: Article
Language:English
Subjects:
Alkaloids
Alkaloids - analysis
Chromatography - methods
Glycosidase inhibitors
Polyhydroxy alkaloids
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Summary:Polyhydroxy alkaloids are a burgeoning category of natural products that encompass several structural types and generally exhibit potent activity as inhibitors of glycosidases. As presently defined the group consists of monocyclic or bicyclic alkaloids of the pyrrolidine, piperidine, pyrrolizidine, indolizidine and tropane classes, bearing two or more hydroxyl groups. These structural features render the compounds highly water soluble and frequently quite insoluble in non-hydroxylic solvents, so that their isolation and analysis by chromatographic means are consequently difficult. This problem is further confounded by the lack of a chromophore which would permit their detection by UV absorption. This review presents chromatographic techniques that have been successfully applied to the problem of isolating, purifying, detecting and analyzing polyhydroxy alkaloids.
ISSN:0021-9673
DOI:10.1016/S0021-9673(01)01558-8