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The increased proliferation of cultured neuroblastoma cells treated with vasoactive intestinal peptide is enhanced by simultaneous inhibition of neutral endopeptidase

Vasoactive intestinal peptide (VIP) stimulates the neuroblastoma cell line (NMB) to proliferate. Neuropeptide activity can be inhibited by neutral endopeptidases that function intracellularly and in the extracellular milieu. NMB cells express neutral endopeptidase (NEP) activity that can be specific...

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Bibliographic Details
Published in:Regulatory peptides 2002-10, Vol.108 (2), p.175-177
Main Authors: Wollman, Yoram, Blumberg, Shmariahu, Spungin, Anya, Brenneman, Douglas E, Fridkin, Mati, Wollman, Jonathan, Iaina, Adrian, Gozes, Illana
Format: Article
Language:English
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Summary:Vasoactive intestinal peptide (VIP) stimulates the neuroblastoma cell line (NMB) to proliferate. Neuropeptide activity can be inhibited by neutral endopeptidases that function intracellularly and in the extracellular milieu. NMB cells express neutral endopeptidase (NEP) activity that can be specifically inhibited by phosphoramidon (PA). Our data now show that phosphoramidon treatment increases the efficacy of VIP-stimulated neuroblastoma proliferation. These results suggest that membrane endopeptidases modulate VIP-associated cell proliferation and enhancement of endopeptidase activity may serve as a target for cancer therapy.
ISSN:0167-0115
1873-1686
DOI:10.1016/S0167-0115(02)00098-8