Dynamic susceptibility contrast-enhanced echo-planar imaging of cerebral gliomas: Effect of contrast medium extravasation

To assess the influence of the degree of contrast medium extravasation on different DSC EPI MR sequences for perfusion MR imaging. 60 patients with cerebral gliomas were examined by either an FID EPI or an SE EPI DSC MR sequence. The acquired images were evaluated on a qualitative and quantitative b...

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Bibliographic Details
Published in:Acta radiologica (1987) 2002-07, Vol.43 (4), p.354-359
Main Authors: ESSIG, M, WENZ, F, SCHOLDEI, R, BRÜNING, R, BERCHTENBREITER, C, MEURER, M, KNOPP, M. V
Format: Article
Language:English
Subjects:
Biological and medical sciences
Brain Neoplasms - diagnosis
Contrast Media
Echo-Planar Imaging - methods
Extravasation of Diagnostic and Therapeutic Materials - diagnosis
Gadolinium DTPA
Glioma - diagnosis
Humans
Injections, Intravenous
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Middle Aged
Nervous system
Radiodiagnosis. Nmr imagery. Nmr spectrometry
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Summary:To assess the influence of the degree of contrast medium extravasation on different DSC EPI MR sequences for perfusion MR imaging. 60 patients with cerebral gliomas were examined by either an FID EPI or an SE EPI DSC MR sequence. The acquired images were evaluated on a qualitative and quantitative basis. For qualitative assessment, the homogeneity of the signal time curve, image artifacts, the degree of signal drop and the degree of enhancement were evaluated. The quantitative assessment included the percentage of signal drop and the contrast-to-noise ratio of the different EPI sequences was analyzed. FID EPI presented a more homogeneous signal time curve and a more pronounced susceptibility effect than the SE EPI sequence. Due to the lesser susceptibility effect, the SE EPI sequence was not as sensitive to contrast media extravasation. The signal returned to baseline in all patients. In patients with strongly enhancing lesions, the FID EPI sequence suffered from considerable T1 effects, causing problems in the quantification of perfusion data. FID EPI sequences were preferred for perfusion MR imaging in patients without strong enhancing lesions, e.g. in ischemia or tumors with intact blood-brain barrier. In patients with suspected strong enhancing lesions, an SE EPI sequence should be used.
ISSN:0284-1851
1600-0455
DOI:10.1034/j.1600-0455.2002.430402.x