Lymphocyte subsets and assessment of cancer risk in renal transplant recipients

Renal transplant recipients have a well‐recognized increased risk of de novo neoplasia. In this study, we investigated whether lymphocyte subset count could predict the risk of developing noncutaneous neoplasia (NCSC) in renal transplant recipients (RTR). Between January 1995 and December 1995, lymp...

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Bibliographic Details
Published in:Transplant international 2002-09, Vol.15 (8), p.393-396
Main Authors: Ducloux, Didier, Carron, Pierre‐Louis, Motte, Gerard, Ab, Abdelfatah, Rebibou, Jean‐Michel, Bresson‐Vautrin, Catherine, Tiberghien, Pierre, Saint‐Hillier, Yves, Chalopin, Jean‐Marc
Format: Article
Language:English
Subjects:
Adult
Aged
Antigens, CD19 - analysis
Biological and medical sciences
Cancer
Carcinogenesis, carcinogens and anticarcinogens
CD4 Lymphocyte Count
Female
General aspects
Humans
Immunosuppression
Kidney Transplantation - adverse effects
Kidney Transplantation - immunology
Lymphocyte subsets
Male
Medical sciences
Middle Aged
Neoplasms - etiology
Renal transplantation
Risk
Tumors
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Summary:Renal transplant recipients have a well‐recognized increased risk of de novo neoplasia. In this study, we investigated whether lymphocyte subset count could predict the risk of developing noncutaneous neoplasia (NCSC) in renal transplant recipients (RTR). Between January 1995 and December 1995, lymphocyte subsets (CD4, CD8, CD19) were measured in 281 RTR. This population was studied until November 1999 for the development of NCSC. The mean follow‐up was 42±9 months. Neoplasm was diagnosed in 22 patients (7.9%). Patients who developed a cancer were significantly older (53.8±6 years vs 38±16 years, P
ISSN:0934-0874
1432-2277
DOI:10.1111/j.1432-2277.2002.tb00187.x