Antidiabetic Activity of Lyophyllum decastes in Genetically Type 2 Diabetic Mice

The antidiabetic activity of Lyophyllum decastes (Tricholomataceae) was investigated in KK-Ay mice, an animal model of genetically type 2 diabetes with hyperinsulinemia. The water extract of Lyophyllum decastes (LD) (500 mg/kg body weight) reduced the blood glucose of KK-Ay mice 7 h after a single o...

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Bibliographic Details
Published in:Biological & pharmaceutical bulletin 2002, Vol.25(9), pp.1234-1237
Main Authors: Miura, Toshihiro, Kubo, Mizue, Itoh, Yasushi, Iwamoto, Naoki, Kato, Motoshi, Park, Sang Rae, Ukawa, Yuuichi, Kita, Yukio, Suzuki, Ikukatsu
Format: Article
Language:English
Subjects:
Animals
antidiabetic activity
Biological and medical sciences
Blood Glucose - metabolism
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - drug therapy
Diabetes Mellitus, Type 2 - genetics
Fruit
General pharmacology
GLUT4
Hypoglycemic Agents - isolation & purification
Hypoglycemic Agents - pharmacology
Hypoglycemic Agents - therapeutic use
Insulin - blood
insulin resistance
KK-Ay
Lyophyllum decastes
Male
Medical sciences
Mice
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phytotherapy - methods
Plant Extracts - isolation & purification
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
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Summary:The antidiabetic activity of Lyophyllum decastes (Tricholomataceae) was investigated in KK-Ay mice, an animal model of genetically type 2 diabetes with hyperinsulinemia. The water extract of Lyophyllum decastes (LD) (500 mg/kg body weight) reduced the blood glucose of KK-Ay mice 7 h after a single oral administration (p
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.25.1234