Cell interactions with three-dimensional matrices

Signaling and other cellular functions differ in three-dimensional compared with two-dimensional systems. Cell adhesion structures can evolve in vitro towards in-vivo-like adhesions with distinct biological activities. In this review, we examine recent advances in studies of interactions of fibrobla...

Full description

Saved in:
Bibliographic Details
Published in:Current Opinion in Cell Biology 2002-10, Vol.14 (5), p.633-640
Main Authors: Cukierman, Edna, Pankov, Roumen, Yamada, Kenneth M
Format: Article
Language:English
Subjects:
3D substrates
3Dsignalling
adhesion
Animals
Cell Adhesion
cell-derived 3D matrix
cell-matrix interactions
Collagen - metabolism
collagen gel
Fibroblasts - metabolism
fibronectin
Fibronectins - metabolism
Humans
Microscopy, Confocal
Models, Biological
Protein Binding
Signal Transduction
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Signaling and other cellular functions differ in three-dimensional compared with two-dimensional systems. Cell adhesion structures can evolve in vitro towards in-vivo-like adhesions with distinct biological activities. In this review, we examine recent advances in studies of interactions of fibroblasts with collagen gels and fibronectin-containing matrices that mimic in vivo three-dimensional microenvironments. These three-dimensional systems are illuminating mechanisms of cell–matrix interactions in living organisms. Cells growing in three-dimensional matrices have different cell adhesions, signaling, and other responses compared to regular cell cultures; these cellular responses depend on the molecular composition, physical properties, and three-dimensionality of the matrix.
ISSN:0955-0674
1879-0410
DOI:10.1016/S0955-0674(02)00364-2