Taurine Treatment Reduces Hepatic Lipids and Oxidative Stress in Chronically Ethanol-Treated Rats

In this study, we evaluated whether taurine treatment has a protective effect on the prooxidant-antioxidant state following chronic ethanol treatment in rats. Rats were given water containing 20% ethanol (v/v) as drinking water for 3 months. Chronic ethanol treatment in drinking water resulted in in...

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Bibliographic Details
Published in:Biological & pharmaceutical bulletin 2002, Vol.25(9), pp.1231-1233
Main Authors: Balkan, Jale, Kanbagli, Öznur, Aykaç-Toker, Gülçin, Uysal, Müjdat
Format: Article
Language:English
Subjects:
Alcoholism and acute alcohol poisoning
Animals
antioxidant
Biological and medical sciences
chronic ethanol
Ethanol - administration & dosage
General and cellular metabolism. Vitamins
Lipid Metabolism
lipid peroxide
Lipids - blood
liver
Liver - drug effects
Liver - metabolism
Male
Medical sciences
Oxidative Stress - drug effects
Oxidative Stress - physiology
Pharmacology. Drug treatments
rat
Rats
Rats, Wistar
taurine
Taurine - pharmacology
Toxicology
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Summary:In this study, we evaluated whether taurine treatment has a protective effect on the prooxidant-antioxidant state following chronic ethanol treatment in rats. Rats were given water containing 20% ethanol (v/v) as drinking water for 3 months. Chronic ethanol treatment in drinking water resulted in increased oxidative stress in the liver of rats. Taurine treatment was performed by adding 1% taurine (w/v) to the drinking water plus injection (400 mg/kg body weight) intraperitoneally 3 times/week for 28 d after ethanol cessation in chronically ethanol-treatad rats. This treatment starting after ethanol cessation caused a significant decreases in serum transaminase activities and hepatic total lipid, triglyceride, malondialdehyde, and diene conjugate levels and significant increases in hepatic glutathione, vitamin E, and vitamin C levels, but did not alter the activities of superoxide dismutase, glutathione peroxidase, and glutathione transferase in the liver as compared with chronically ethanol-treated rats. Accordingly, we propose that taurine has a restorative effect on ethanol-induced hepatic damage by decreasing oxidative stres.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.25.1231