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Unusual Sulfamate Indoles and a Novel Indolo[3,2-a]carbazole from Ancorina sp

Four new indoles, ancorinolates A−C and bis-ancorinolate B, which contain sulfamate and sulfate groups, were isolated from the aqueous extract of the sponge Ancorina sp. In addition, ancorinazole, an indolo[3,2-a]carbazole also possessing sulfamate and sulfate groups, was isolated from two separate...

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Published in:	Journal of organic chemistry 2002-09, Vol.67 (19), p.6671-6677
Main Authors:	Meragelman, Karina M, West, Lyndon M, Northcote, Peter T, Pannell, Lewis K, McKee, Tawnya C, Boyd, Michael R
Format:	Article
Language:	English
Subjects:	Acetylation Animals Anti-HIV Agents - chemistry Anti-HIV Agents - isolation & purification Anti-HIV Agents - pharmacology Biological and medical sciences Chromatography, High Pressure Liquid General pharmacology Hydrolysis Indoles - chemistry Indoles - isolation & purification Indoles - pharmacology Mass Spectrometry Medical sciences Molecular Structure New Zealand Nuclear Magnetic Resonance, Biomolecular Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Porifera - chemistry
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container_end_page	6677
container_issue	19
container_start_page	6671
container_title	Journal of organic chemistry
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creator	Meragelman, Karina M West, Lyndon M Northcote, Peter T Pannell, Lewis K McKee, Tawnya C Boyd, Michael R
description	Four new indoles, ancorinolates A−C and bis-ancorinolate B, which contain sulfamate and sulfate groups, were isolated from the aqueous extract of the sponge Ancorina sp. In addition, ancorinazole, an indolo[3,2-a]carbazole also possessing sulfamate and sulfate groups, was isolated from two separate New Zealand collections of Ancorina sp. Ancorinazole is the first indolo[3,2-a]carbazole described as a natural product. Ancorinolates A (1) and C (3) showed weak HIV-inhibitory activity in the XTT-based, anticytopathicity assay.
doi_str_mv	10.1021/jo020120k
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Org. Chem</addtitle><description>Four new indoles, ancorinolates A−C and bis-ancorinolate B, which contain sulfamate and sulfate groups, were isolated from the aqueous extract of the sponge Ancorina sp. In addition, ancorinazole, an indolo[3,2-a]carbazole also possessing sulfamate and sulfate groups, was isolated from two separate New Zealand collections of Ancorina sp. Ancorinazole is the first indolo[3,2-a]carbazole described as a natural product. 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Drug treatments</topic><topic>Porifera - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Meragelman, Karina M</creatorcontrib><creatorcontrib>West, Lyndon M</creatorcontrib><creatorcontrib>Northcote, Peter T</creatorcontrib><creatorcontrib>Pannell, Lewis K</creatorcontrib><creatorcontrib>McKee, Tawnya C</creatorcontrib><creatorcontrib>Boyd, Michael R</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of organic chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Meragelman, Karina M</au><au>West, Lyndon M</au><au>Northcote, Peter T</au><au>Pannell, Lewis K</au><au>McKee, Tawnya C</au><au>Boyd, Michael R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Unusual Sulfamate Indoles and a Novel Indolo[3,2-a]carbazole from Ancorina sp</atitle><jtitle>Journal of organic chemistry</jtitle><addtitle>J. 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subjects	Acetylation Animals Anti-HIV Agents - chemistry Anti-HIV Agents - isolation & purification Anti-HIV Agents - pharmacology Biological and medical sciences Chromatography, High Pressure Liquid General pharmacology Hydrolysis Indoles - chemistry Indoles - isolation & purification Indoles - pharmacology Mass Spectrometry Medical sciences Molecular Structure New Zealand Nuclear Magnetic Resonance, Biomolecular Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Porifera - chemistry
title	Unusual Sulfamate Indoles and a Novel Indolo[3,2-a]carbazole from Ancorina sp
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