Effect of chronic renal failure on the purinergic responses of corpus cavernosal smooth muscle in rabbits

• Published in: BJU international 2002-10, Vol.90 (6), p.596-600
• Main Authors: Kilicarslan, H., Yildirim, S., Bagcivan, I., Ayan, S., Sarac, B., Sarioglu, Y.
• Format: Article
• Language: English
• Subjects: Adenosine - pharmacology; Adenosine Triphosphate - pharmacology; Animals; Biological and medical sciences; corpus cavernosum; CRF; Erectile Dysfunction - etiology; impotence; Kidney Failure, Chronic - complications; Male; Medical sciences; Muscle, Smooth - drug effects; Muscle, Smooth - physiopathology; Nephrology. Urinary tract diseases; Nephropathies. Renovascular diseases. Renal failure; purinergic relaxation; rabbit; Rabbits; Receptors, Purinergic - metabolism; Renal failure
• ISSN: 1464-4096; 1464-410X
• DOI: 10.1046/j.1464-410X.2002.02979.x

Objective  To examine purinergic relaxation responses in chronic renal failure (CRF) in an experimental rabbit model, and thus evaluate the possible involvement of the purinergic system in erectile dysfunction with CRF. Materials and methods  The relaxant effects of ATP were measured in strips of corpus cavernosum smooth muscle taken from control and CRF rabbits. CRF was induced in New Zealand white rabbits as previously described. Penises were excised from CRF rabbits 4 weeks after inducing uraemia. In an organ bath the strips from controls and CRF rabbit corpus cavernosum were pre‐contracted with phenylephrine and increasing doses of adenosine and ATP added. Results  In the pre‐contracted rabbit cavernosal tissue the relaxations induced by adenosine and ATP were unchanged in CRF. Conclusion  The lack of any relaxant effect of adenosine or ATP on the relaxation of cavernosal smooth muscle in rabbits with CRF might be because the relaxant effects of these agents are endothelium‐independent and the endothelial purinergic receptor density was unchanged in CRF.