Interleukin 10 (IL-10) influences autoimmune response in primary Sjögren's syndrome and is linked to IL-10 gene polymorphism

To investigate the association between serum levels of interleukin 10 (IL-10), the synthesis of autoantibodies, salivary gland disease activity, clinical manifestations, and IL-10 microsatellite polymorphism in patients with primary Sjögren's syndrome (pSS). Serum IL-10 and autoantibody levels...

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Bibliographic Details
Published in:Journal of rheumatology 2002-09, Vol.29 (9), p.1874-1876
Main Authors: Anaya, Juan-Manuel, Correa, Paula A, Herrera, Mónica, Eskdale, Joyce, Gallagher, Grant
Format: Article
Language:English
Subjects:
Adult
Autoantibodies - analysis
Autoimmunity - physiology
Case-Control Studies
Chi-Square Distribution
Enzyme-Linked Immunosorbent Assay
Female
Humans
Interleukin-10 - blood
Interleukin-10 - genetics
Male
Middle Aged
Polymorphism, Genetic
Probability
Prognosis
Sensitivity and Specificity
Severity of Illness Index
Sjogren's Syndrome - genetics
Sjogren's Syndrome - immunology
Statistics, Nonparametric
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Summary:To investigate the association between serum levels of interleukin 10 (IL-10), the synthesis of autoantibodies, salivary gland disease activity, clinical manifestations, and IL-10 microsatellite polymorphism in patients with primary Sjögren's syndrome (pSS). Serum IL-10 and autoantibody levels [IgG anti-Ro and anti-La, total and IgA rheumatoid factor (RF)] were measured by ELISA. A minor salivary gland (MSG) biopsy was performed in all patients and the focus score was determined as a measure of salivary gland disease activity. In addition, IL-10 microsatellite typing was performed by polymerase chain reaction technique. IL-10 concentration was higher in patients (n = 39) than in controls (n = 15) (21.4 +/- 6.7 vs 2.5 +/- 3.5 pg/ml; p = 0.001). We found a significant positive correlation between IL-10 levels and titers of IgA RF, anti-Ro, and anti-La antibodies, as well as focus score. In comparison with patients with low IL-10 production (< 9.5 pg/ml), patients producing high IL-10 had significantly more episodes of cutaneous vasculitis and a higher proportion of them carried the IL-10.G9 allele. Autoimmune response in pSS patients as well as salivary gland disease activity and cutaneous involvement appears to be mediated by IL-10 levels; in turn, there is a linkage with IL-10 gene polymorphism.
ISSN:0315-162X