The tau locus is not significantly associated with pathologically confirmed sporadic Parkinson's disease

Mutations of the tau gene in frontotemporal dementia with parkinsonism and genetic association of the tau locus with progressive supranuclear palsy and corticobasal degeneration directly implicate the tau gene in the aetiology of these tauopathies. Three studies have also shown an association of the...

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Bibliographic Details
Published in:Neuroscience letters 2002-09, Vol.330 (2), p.201-203
Main Authors: de Silva, Rohan, Hardy, John, Crook, Julia, Khan, Naheed, Graham, Elizabeth A, Morris, Christopher M, Wood, Nicholas W, Lees, Andrew J
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Alleles
Biological and medical sciences
Case-Control Studies
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Female
Gene Frequency
Genetics
Genotype
Haplotypes
Humans
Linkage Disequilibrium
Male
Medical sciences
Middle Aged
Mutation - genetics
Neurodegeneration
Neurology
Parkinson Disease - diagnosis
Parkinson Disease - genetics
Parkinson's disease
Polymerase Chain Reaction
Polymorphism, Genetic
Tau
tau Proteins - genetics
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Summary:Mutations of the tau gene in frontotemporal dementia with parkinsonism and genetic association of the tau locus with progressive supranuclear palsy and corticobasal degeneration directly implicate the tau gene in the aetiology of these tauopathies. Three studies have also shown an association of the tau locus with clinically diagnosed Parkinson's disease. Noting the significant incidence of clinical misdiagnosis of Parkinson's disease, we investigated this tau gene association in a series of 157 pathologically confirmed cases of brain stem Lewy body Parkinson's disease by analysing their tau haplotype status. Although H1H1 homozygotes are elevated in the Parkinson's disease cases (63.1%) compared to controls (56.1%) this difference is not significant ( P=0.22). These results indicate that any association must either be weak (with an odds ratio of less than 2) or that previous positive associations were due to contamination of clinically diagnosed cases with other diagnostic clinico-pathological entities such as neurofibrillary tangle Parkinson's syndrome.
ISSN:0304-3940
1872-7972
DOI:10.1016/S0304-3940(02)00742-5