TASK-1, TASK-2, TASK-3 and TRAAK immunoreactivities in the rat carotid body

• Published in: Brain research 2002-09, Vol.950 (1), p.304-307
• Main Authors: Yamamoto, Yoshio, Kummer, Wolfgang, Atoji, Yasuro, Suzuki, Yoshitaka
• Format: Article
• Language: English
• Subjects: Animals; Biological and medical sciences; Cardiorespiratory control. Arterial mecano- and chemoreceptor; Carotid body; Carotid Body - chemistry; Carotid Body - cytology; Female; Fundamental and applied biological sciences. Psychology; Immunohistochemistry; Male; Nerve Tissue Proteins - analysis; Potassium Channels - analysis; Potassium Channels, Tandem Pore Domain; Rat; Rats; Rats, Wistar; Two pore potassium channel; Vertebrates: respiratory system
• ISSN: 0006-8993; 1872-6240
• DOI: 10.1016/S0006-8993(02)03181-5

In the present study, we investigated the immunohistochemical localization of two-pore K +-channels TASK-1, TASK-2, TASK-3 and TRAAK in the rat carotid body. Type I cells were positive for TASK-1, TASK-2, TASK-3 and TRAAK. Intrinsic nerve cell bodies were also strongly positive for TASK-1, TASK-2 and TRAAK, but negative for TASK-3. In addition, some type II cells, Schwann cells in the nerve bundles and fibroblast between type I cell clusters were also immunostained for TASK-1. Smooth muscle cells of the carotid body artery were intensely positive for TASK-3. Our results indicate that TASK-1 immunoreactivity was ubiquitously distributed in many cell types and immunoreactivities for TASK-2, TASK-3 and TRAAK were cell type specific distribution patterns in the rat carotid body.