Bactericidal activity of Ag–zeolite mediated by reactive oxygen species under aerated conditions

The bactericidal activity induced by the introduction of silver ions into zeolite was studied. Escherichia coli was used as the test microorganism. Silver ions were loaded into zeolite by the ion-exchange method. Silver-loaded zeolite was demonstrated the strong bactericidal activity. Dissolved oxyg...

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Bibliographic Details
Published in:Journal of inorganic biochemistry 2002-09, Vol.92 (1), p.37-42
Main Authors: Inoue, Yoshihiro, Hoshino, Masanobu, Takahashi, Hiroo, Noguchi, Tomoko, Murata, Tomomi, Kanzaki, Yasushi, Hamashima, Hajime, Sasatsu, Masanori
Format: Article
Language:English
Subjects:
Aerobiosis
Anti-Bacterial Agents - pharmacology
Bactericidal activity
Catalase - metabolism
Cytochrome c Group - metabolism
Escherichia coli - drug effects
Escherichia coli - growth & development
Escherichia coli - metabolism
Free Radical Scavengers - metabolism
Hydrogen Peroxide - metabolism
Hydroxyl Radical - metabolism
Nitrogen - pharmacology
Oxygen - metabolism
Reactive oxygen species
Reactive Oxygen Species - metabolism
Silver
Singlet Oxygen - metabolism
Solvents
Superoxides - metabolism
Zeolite
Zeolites - pharmacology
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Summary:The bactericidal activity induced by the introduction of silver ions into zeolite was studied. Escherichia coli was used as the test microorganism. Silver ions were loaded into zeolite by the ion-exchange method. Silver-loaded zeolite was demonstrated the strong bactericidal activity. Dissolved oxygen was an essential factor for the occurrence of the bactericidal activity because the activity was observed only under aerated condition. Superoxide anions, hydrogen peroxide, hydroxyl radicals and singlet oxygen were formed. Scavengers of these each reactive oxygen species (ROS) inhibited the bactericidal activity. This means that all ROS contributed to the activity.
ISSN:0162-0134
1873-3344
DOI:10.1016/S0162-0134(02)00489-0