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Sex-selective QT prolongation during rapid eye movement sleep
We examined the effects of the various sleep stages on RR and QT intervals in healthy subjects and tested the hypothesis that there is a differential effect of sleep stage on QT interval in women compared with men. Eighteen healthy subjects (9 women, age 22 to 45 years) underwent polysomnography and...
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Published in: | Circulation (New York, N.Y.) N.Y.), 2002-09, Vol.106 (12), p.1488-1492 |
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container_title | Circulation (New York, N.Y.) |
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creator | LANFRANCHI, Paola A SHAMSUZZAMAN, Abu S. M ACKERMAN, Michael J KARA, Tomas JURAK, Pavel WOLK, Robert SOMERS, Virend K |
description | We examined the effects of the various sleep stages on RR and QT intervals in healthy subjects and tested the hypothesis that there is a differential effect of sleep stage on QT interval in women compared with men.
Eighteen healthy subjects (9 women, age 22 to 45 years) underwent polysomnography and simultaneous recording of ECG, blood pressure, and respiration. RR interval, RR variability, and QT values were measured in stable conditions (no abrupt changes of heart rate or blood pressure, stable breathing pattern) during inactive wakefulness during stages 2 and 3 to 4 of non-REM sleep and during REM sleep. The absolute QT interval was normalized for variations of RR (QTc). In men, RR interval and RR variability increased through all sleep stages. The QTc remained stable from wakefulness through all sleep stages. In women, however, RR interval increased only during non-REM and was virtually identical in wakefulness and in REM. RR variability remained very stable from wakefulness through all stages of sleep. Also, during REM in women, both absolute QT interval and QTc, regardless of the correction maneuver used, increased compared with wakefulness.
The influence of sleep on RR, RR variability, and QTc is sex-dependent. We speculate that these differential sex effects on cardiac rate and repolarization may have important implications for sleep-selected cardiac arrhythmias in women. |
doi_str_mv | 10.1161/01.cir.0000030183.10934.95 |
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Eighteen healthy subjects (9 women, age 22 to 45 years) underwent polysomnography and simultaneous recording of ECG, blood pressure, and respiration. RR interval, RR variability, and QT values were measured in stable conditions (no abrupt changes of heart rate or blood pressure, stable breathing pattern) during inactive wakefulness during stages 2 and 3 to 4 of non-REM sleep and during REM sleep. The absolute QT interval was normalized for variations of RR (QTc). In men, RR interval and RR variability increased through all sleep stages. The QTc remained stable from wakefulness through all sleep stages. In women, however, RR interval increased only during non-REM and was virtually identical in wakefulness and in REM. RR variability remained very stable from wakefulness through all stages of sleep. Also, during REM in women, both absolute QT interval and QTc, regardless of the correction maneuver used, increased compared with wakefulness.
The influence of sleep on RR, RR variability, and QTc is sex-dependent. We speculate that these differential sex effects on cardiac rate and repolarization may have important implications for sleep-selected cardiac arrhythmias in women.</description><identifier>ISSN: 0009-7322</identifier><identifier>EISSN: 1524-4539</identifier><identifier>DOI: 10.1161/01.cir.0000030183.10934.95</identifier><identifier>PMID: 12234953</identifier><identifier>CODEN: CIRCAZ</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adult ; Arrhythmias, Cardiac - etiology ; Biological and medical sciences ; Blood Pressure ; Cardiac dysrhythmias ; Cardiology. Vascular system ; Electrocardiography ; Female ; Heart ; Humans ; Medical sciences ; Middle Aged ; Polysomnography ; Respiratory Mechanics ; Sex Factors ; Sleep Stages ; Sleep, REM - physiology ; Wakefulness</subject><ispartof>Circulation (New York, N.Y.), 2002-09, Vol.106 (12), p.1488-1492</ispartof><rights>2002 INIST-CNRS</rights><rights>Copyright American Heart Association, Inc. Sep 17, 2002</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c590t-aa63e815f43cf3bf50ec9a174bdd4ddc91f62be3229e53a902e034a673257cc63</citedby><cites>FETCH-LOGICAL-c590t-aa63e815f43cf3bf50ec9a174bdd4ddc91f62be3229e53a902e034a673257cc63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13931420$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12234953$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LANFRANCHI, Paola A</creatorcontrib><creatorcontrib>SHAMSUZZAMAN, Abu S. M</creatorcontrib><creatorcontrib>ACKERMAN, Michael J</creatorcontrib><creatorcontrib>KARA, Tomas</creatorcontrib><creatorcontrib>JURAK, Pavel</creatorcontrib><creatorcontrib>WOLK, Robert</creatorcontrib><creatorcontrib>SOMERS, Virend K</creatorcontrib><title>Sex-selective QT prolongation during rapid eye movement sleep</title><title>Circulation (New York, N.Y.)</title><addtitle>Circulation</addtitle><description>We examined the effects of the various sleep stages on RR and QT intervals in healthy subjects and tested the hypothesis that there is a differential effect of sleep stage on QT interval in women compared with men.
Eighteen healthy subjects (9 women, age 22 to 45 years) underwent polysomnography and simultaneous recording of ECG, blood pressure, and respiration. RR interval, RR variability, and QT values were measured in stable conditions (no abrupt changes of heart rate or blood pressure, stable breathing pattern) during inactive wakefulness during stages 2 and 3 to 4 of non-REM sleep and during REM sleep. The absolute QT interval was normalized for variations of RR (QTc). In men, RR interval and RR variability increased through all sleep stages. The QTc remained stable from wakefulness through all sleep stages. In women, however, RR interval increased only during non-REM and was virtually identical in wakefulness and in REM. RR variability remained very stable from wakefulness through all stages of sleep. Also, during REM in women, both absolute QT interval and QTc, regardless of the correction maneuver used, increased compared with wakefulness.
The influence of sleep on RR, RR variability, and QTc is sex-dependent. We speculate that these differential sex effects on cardiac rate and repolarization may have important implications for sleep-selected cardiac arrhythmias in women.</description><subject>Adult</subject><subject>Arrhythmias, Cardiac - etiology</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure</subject><subject>Cardiac dysrhythmias</subject><subject>Cardiology. Vascular system</subject><subject>Electrocardiography</subject><subject>Female</subject><subject>Heart</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Polysomnography</subject><subject>Respiratory Mechanics</subject><subject>Sex Factors</subject><subject>Sleep Stages</subject><subject>Sleep, REM - physiology</subject><subject>Wakefulness</subject><issn>0009-7322</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><recordid>eNpdkNtKxDAQhoMouq6-ghRB71qTTNJuBC9k8bCwIOp6HbLpVCo9mbSib2_WLSyYmyHMNzM_HyHnjCaMpeyKssSWLqGbB5TNIGFUgUiU3CMTJrmIhQS1Tyahr-IMOD8ix95_hG8KmTwkR4xzEErChNy84nfssULbl18YPa-izrVV27ybvmybKB9c2bxHznRlHuEPRnX7hTU2feQrxO6EHBSm8ng61il5u79bzR_j5dPDYn67jK1UtI-NSQFnTBYCbAHrQlK0yrBMrPNc5LlVrEj5GkNQhRKMohwpCJOG6DKzNoUpudzuDeE-B_S9rktvsapMg-3gdcapSmlGA3j-D_xoB9eEbJoznmbZTECArreQda33DgvdubI27kczqjeGNWV6vnjRO8P6z7AOyqbkbLwwrGvMd6Oj0gBcjIDx1lSFM40t_Y4DBUxwCr9yW4Nt</recordid><startdate>20020917</startdate><enddate>20020917</enddate><creator>LANFRANCHI, Paola A</creator><creator>SHAMSUZZAMAN, Abu S. M</creator><creator>ACKERMAN, Michael J</creator><creator>KARA, Tomas</creator><creator>JURAK, Pavel</creator><creator>WOLK, Robert</creator><creator>SOMERS, Virend K</creator><general>Lippincott Williams & Wilkins</general><general>American Heart Association, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope></search><sort><creationdate>20020917</creationdate><title>Sex-selective QT prolongation during rapid eye movement sleep</title><author>LANFRANCHI, Paola A ; SHAMSUZZAMAN, Abu S. M ; ACKERMAN, Michael J ; KARA, Tomas ; JURAK, Pavel ; WOLK, Robert ; SOMERS, Virend K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c590t-aa63e815f43cf3bf50ec9a174bdd4ddc91f62be3229e53a902e034a673257cc63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Arrhythmias, Cardiac - etiology</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure</topic><topic>Cardiac dysrhythmias</topic><topic>Cardiology. Vascular system</topic><topic>Electrocardiography</topic><topic>Female</topic><topic>Heart</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Polysomnography</topic><topic>Respiratory Mechanics</topic><topic>Sex Factors</topic><topic>Sleep Stages</topic><topic>Sleep, REM - physiology</topic><topic>Wakefulness</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LANFRANCHI, Paola A</creatorcontrib><creatorcontrib>SHAMSUZZAMAN, Abu S. M</creatorcontrib><creatorcontrib>ACKERMAN, Michael J</creatorcontrib><creatorcontrib>KARA, Tomas</creatorcontrib><creatorcontrib>JURAK, Pavel</creatorcontrib><creatorcontrib>WOLK, Robert</creatorcontrib><creatorcontrib>SOMERS, Virend K</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LANFRANCHI, Paola A</au><au>SHAMSUZZAMAN, Abu S. 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Eighteen healthy subjects (9 women, age 22 to 45 years) underwent polysomnography and simultaneous recording of ECG, blood pressure, and respiration. RR interval, RR variability, and QT values were measured in stable conditions (no abrupt changes of heart rate or blood pressure, stable breathing pattern) during inactive wakefulness during stages 2 and 3 to 4 of non-REM sleep and during REM sleep. The absolute QT interval was normalized for variations of RR (QTc). In men, RR interval and RR variability increased through all sleep stages. The QTc remained stable from wakefulness through all sleep stages. In women, however, RR interval increased only during non-REM and was virtually identical in wakefulness and in REM. RR variability remained very stable from wakefulness through all stages of sleep. Also, during REM in women, both absolute QT interval and QTc, regardless of the correction maneuver used, increased compared with wakefulness.
The influence of sleep on RR, RR variability, and QTc is sex-dependent. We speculate that these differential sex effects on cardiac rate and repolarization may have important implications for sleep-selected cardiac arrhythmias in women.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>12234953</pmid><doi>10.1161/01.cir.0000030183.10934.95</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adult Arrhythmias, Cardiac - etiology Biological and medical sciences Blood Pressure Cardiac dysrhythmias Cardiology. Vascular system Electrocardiography Female Heart Humans Medical sciences Middle Aged Polysomnography Respiratory Mechanics Sex Factors Sleep Stages Sleep, REM - physiology Wakefulness |
title | Sex-selective QT prolongation during rapid eye movement sleep |
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