Polymorphism of CYP2C19 and Gastric Emptying in Patients with Proton Pump Inhibitor-Resistant Gastric Ulcers

The aim of the present study was to investigate whether CYP2C19 polymorphism status and gastric emptying are related to healing in patients with gastric ulcers. We studied the CYP2C19 status in seven patients with proton pump inhibitor (PPI)-resistant ulcers, 21 with PPI-sensitive ulcers and 46 heal...

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Bibliographic Details
Published in:Journal of international medical research 2002-07, Vol.30 (4), p.413-421
Main Authors: Wada, F, Murase, K, Isomoto, H, Soda, H, Takeshima, F, Omagari, K, Mizuta, Y, Tsukamoto, K, Murata, I, Kohno, S
Format: Article
Language:English
Subjects:
2-Pyridinylmethylsulfinylbenzimidazoles
Adult
Anti-Ulcer Agents - therapeutic use
Aryl Hydrocarbon Hydroxylases - genetics
Aryl Hydrocarbon Hydroxylases - physiology
Benzimidazoles - therapeutic use
Cytochrome P-450 CYP2C19
Female
Gastric Emptying - genetics
Gastric Emptying - physiology
Humans
Lansoprazole
Male
Middle Aged
Mixed Function Oxygenases - genetics
Mixed Function Oxygenases - physiology
Omeprazole - analogs & derivatives
Omeprazole - therapeutic use
Polymorphism, Genetic - physiology
Proton Pump Inhibitors
Rabeprazole
Stomach Ulcer - drug therapy
Stomach Ulcer - enzymology
Stomach Ulcer - genetics
Stomach Ulcer - physiopathology
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Summary:The aim of the present study was to investigate whether CYP2C19 polymorphism status and gastric emptying are related to healing in patients with gastric ulcers. We studied the CYP2C19 status in seven patients with proton pump inhibitor (PPI)-resistant ulcers, 21 with PPI-sensitive ulcers and 46 healthy volunteers using polymerase chain reaction restriction fragment length polymorphism to detect CYP2C19m1 mutation in exon 5 and CYP2C19m2 mutation in exon 4. Gastric emptying was evaluated using the 13C-acetate breath test. The frequency of phenotypes, indicated by genotypes, did not differ significantly between the three patient groups. The peak time of 13C excretion in patients with PPI-resistant ulcers was significantly longer than that of patients with PPI-sensitive ulcers and healthy volunteers. Our results suggest that rate of gastric emptying, but not CYP2C19 polymorphism, is likely to be an important factor in the delayed healing of patients with PPI-resistant gastric ulcer.
ISSN:0300-0605
1473-2300
DOI:10.1177/147323000203000408