The World Health Organization (WHO) classification of the myeloid neoplasms

A World Health Organization (WHO) classification of hematopoietic and lymphoid neoplasms has recently been published. This classification was developed through the collaborative efforts of the Society for Hematopathology, the European Association of Hematopathologists, and more than 100 clinical hem...

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Bibliographic Details
Published in:Blood 2002-10, Vol.100 (7), p.2292-2302
Main Authors: Vardiman, James W., Harris, Nancy Lee, Brunning, Richard D.
Format: Article
Language:English
Subjects:
Anemias. Hemoglobinopathies
Biological and medical sciences
Diseases of red blood cells
Hematologic and hematopoietic diseases
Humans
Leukemia - classification
Leukemia, Myeloid, Acute - classification
Leukemia, Myeloid, Acute - genetics
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lymphoma - classification
Medical sciences
Myelodysplastic Syndromes - classification
Myelodysplastic Syndromes - genetics
Myeloproliferative Disorders - classification
Myeloproliferative Disorders - genetics
World Health Organization
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Summary:A World Health Organization (WHO) classification of hematopoietic and lymphoid neoplasms has recently been published. This classification was developed through the collaborative efforts of the Society for Hematopathology, the European Association of Hematopathologists, and more than 100 clinical hematologists and scientists who are internationally recognized for their expertise in hematopoietic neoplasms. For the lymphoid neoplasms, this classification provides a refinement of the entities described in the Revised European-American Lymphoma (REAL) Classification—a system that is now used worldwide. To date, however, there has been no published explanation or rationale given for the WHO classification of the myeloid neoplasms. The purpose of this communication is to outline briefly the WHO classification of malignant myeloid diseases, to draw attention to major differences between it and antecedent classification schemes, and to provide the rationale for those differences.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood-2002-04-1199