Serum levels of circulating intercellular adhesion molecule 1 in human malignant melanoma

Current reports have suggested a role for intracellular adhesion molecule 1 (ICAM-1) in the progression of human malignant melanoma and other cancers. Stage I, II, and III patients with histologically diagnosed malignant melanoma had significantly increased serum levels of circulating ICAM-1 (cICAM-...

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Bibliographic Details
Published in:Cancer research (Baltimore) 1991-09, Vol.51 (18), p.5003-5005
Main Authors: HARNING, R, MAINOLFI, E, BYSTRYN, J.-C, HENN, M, MERLUZZI, V. J, ROTHLEIN, R
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Cell Adhesion Molecules - blood
Dermatology
Female
Humans
Intercellular Adhesion Molecule-1
Male
Medical sciences
Melanoma - blood
Melanoma - mortality
Middle Aged
Prognosis
Tumors of the skin and soft tissue. Premalignant lesions
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Summary:Current reports have suggested a role for intracellular adhesion molecule 1 (ICAM-1) in the progression of human malignant melanoma and other cancers. Stage I, II, and III patients with histologically diagnosed malignant melanoma had significantly increased serum levels of circulating ICAM-1 (cICAM-1) and a striking increase in the incidence of positive sera. In Stage II and III patients, the level of cICAM-1 was inversely correlated with survival. Patients with elevated levels of serum cICAM-1 (greater than 2 SD units above control mean) had a significantly shorter mean survival. We suggest that elevated levels of serum cICAM-1 may be of diagnostic and prognostic importance in patients with malignant cutaneous melanoma.
ISSN:0008-5472
1538-7445