Protection of DNA and microsomal membranes in vitro by Glycyrrhiza glabra L. against gamma irradiation

The radioprotective effect of the root extract of Glycyrrhiza glabra L on lipid peroxidation in rat liver microsomes and plasmid pBR322 DNA was investigated. The extract was found to protect microsomal membranes, as evident from reduction in lipid peroxidation, and could also protect plasmid DNA fro...

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Bibliographic Details
Published in:Phytotherapy research 2002-09, Vol.16 (6), p.576-578
Main Authors: Shetty, T. K., Satav, J. G., Nair, C. K. K.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
DNA Damage - drug effects
DNA Damage - radiation effects
G. glabra L
gamma radiation
Gamma Rays
General pharmacology
Glycyrrhiza
In Vitro Techniques
Intracellular Membranes - drug effects
Intracellular Membranes - radiation effects
Male
Medical sciences
microsomal lipid peroxidation
Microsomes - drug effects
Microsomes - radiation effects
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Extracts - pharmacology
Plant Roots - chemistry
plasmid DNA
Plasmids - drug effects
Plasmids - radiation effects
Rats
Rats, Wistar
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Summary:The radioprotective effect of the root extract of Glycyrrhiza glabra L on lipid peroxidation in rat liver microsomes and plasmid pBR322 DNA was investigated. The extract was found to protect microsomal membranes, as evident from reduction in lipid peroxidation, and could also protect plasmid DNA from radiation‐induced strand breaks. Copyright © 2002 John Wiley & Sons, Ltd.
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.927