Comparison of s‐phase fraction, working formulation, and kiel classification in non‐Hodgkin's lymphoma

The prognostic value of S‐phase fraction (SPF), determined by flow cytometric study from paraffin‐embedded tissue, and grading by Working Formulation (WF) and Kiel classification were compared among 245 patients with non‐Hodgkin's lymphoma followed for the median of 89 months or until death. Hi...

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Bibliographic Details
Published in:Cancer 1991-10, Vol.68 (7), p.1564-1571
Main Authors: Joensuu, Heikki, Klemi, Pekka J., Söderström, Karl‐Ove, Jalkanen, Sirpa
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Biological and medical sciences
DNA, Neoplasm - analysis
Female
Flow Cytometry
Hematologic and hematopoietic diseases
Humans
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lymphoma, Non-Hodgkin - classification
Lymphoma, Non-Hodgkin - genetics
Lymphoma, Non-Hodgkin - pathology
Male
Medical sciences
Middle Aged
Multivariate Analysis
Ploidies
Prognosis
Proportional Hazards Models
S Phase
Survival Analysis
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Summary:The prognostic value of S‐phase fraction (SPF), determined by flow cytometric study from paraffin‐embedded tissue, and grading by Working Formulation (WF) and Kiel classification were compared among 245 patients with non‐Hodgkin's lymphoma followed for the median of 89 months or until death. Histologic reclassification and SPF determinations were done without knowledge on clinical data. SPF (P equals 0.0001), WF (P equals 0.0003), and Kiel classification (P equals 0.0008) were associated with mortality in lymphoma in a univariate analysis, and WF and SPF were independent prognostic factors in Cox's multivariate analysis. Although SPF correlated strongly both with WF and Kiel grades (P less than 0.0001), low‐grade and high‐grade malignant lymphomas according to Kiel classification, and highgrade lymphomas according to WF could be divided into groups with significantly different outcome by SPF. The results suggests a role for SPF in therapeutic decision‐making.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19911001)68:7<1564::AID-CNCR2820680718>3.0.CO;2-#